Comparison of the Long-Term Success of Different CAD-CAM Blocks Used as Indirect Restorations in Molar Incisor Hypomineralized Teeth: A Split Mouth Study

This study is about the long-term survival success of different, externally prepared fillings (Indirect restoration, CAD-CAM blocks) used in teeth with reduced mineral structure, namely Molar Incisor Hypomineralization (MIH), which is called chalk teeth in children.

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Key information

Conditions

Molar Hypomineralization, Incisor Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Dental Enamel Hypomineralization Developmental Defects of Enamel Molar Hypomineralization Stomatognathic Diseases Stomatognathic System Abnormalities Tooth Abnormalities Tooth Diseases

Age range

8 year–15 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Necmettin Erbakan University

Konya, Meram, 42090, Turkey (Türkiye)

About this study

The aim of this study was to comparatively evaluate the long-term survival times and clinical success of nano-ceramic hybrid CAD-CAM blocks, Grandio Blocs (R) (VOCO), and glass-ceramic blocks, GC INITIAL LiSi (GC AMERICA INC. USA), according to USPHS criteria, after pulpal treatment in mandibular teeth with bilateral moderate molar incisor hypomineralization.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

8-15 years old

Systemically healthy
Cooperative (Frankl 3-4)
Diagnosed with MIH for at least one permanent tooth
Symmetrical mandibular molars that fit the middle MIH classification (teeth with a tooth score of 7-9 in MIHSI)
Teeth without indication for root canal treatment
Teeth without percussion, abscess and fistula formation
Without periapical lesions
With post-eruption enamel fractures in the relevant teeth
Without mobility and pathological gingival pockets
Patients who agreed to participate in the study.

Exclusion criteria

Teeth that are suitable for mild and severe classification

Non-cooperative (Frankl 1 and Frankl 2)
Teeth with extraction indication
Teeth that require root canal treatment
Teeth with periapical lesions, abscesses and fistula formation
Patients with mobility and pathological gingival pockets

Treatment and study plan

CAD-CAM, indirect restorations

Other

Indirect restorations that we think will last longer than traditional filling materials in teeth with molar hypomineralization.

Primary outcomes

the clinical status of the restorations

Time frame: up to 6 months after intervention

The restorations were clinically evaluated in the oral cavity using the USPHS index.
the status of the periapical tissues

Time frame: Up to the 6th months

The periapical tissue status was assessed according to the Periapical Index (PAI).

Sponsors and collaborators

Lead sponsor

Necmettin Erbakan University

Other

Registry information

Important dates

Study start: 2024
Primary completion: 2024
Study completion: 2025
First posted: Aug 27, 2025
Registry last updated: Aug 27, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed