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NCT Number: NCT05539742

Comparison of the Effect of MCFA and LCFA on Postprandial Appetite and Lipemia

The main objective is to investigate if foods high in coconut oil (MCFA) or palm oil (LCFA) have different impacts on postprandial blood lipid levels and appetite via a visual analog scale (VAS).

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Key information

Conditions

Lipemia Dyslipidemias Hyperlipidemias Lipid Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The University of Jordan, Amman, Jordan

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About this study

Postprandial lipemia has been recognized as a cardiovascular disease risk factor. The rate of postprandial triglyceride production and clearance in the blood, as well as the appetite, are influenced by the quality of the food consumed, such as the length of saturated fatty acids. The study will include 24 healthy adults ranging in age from 18 to 40 years old, of both sexes and it will be conducted at the University of Jordan. The study will involve two experimental test days, each separated by at least a week of washout interval, and each test day will last for 6 hours. All subjects will be randomly assigned to one of the experimental meals using computer-generated tables. Blood serum samples (2 mL) will be taken after an overnight fast and 2, 4, and 6 hours after eating the meals, and blood lipid profiles [total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG)] will be examined in a private lab. After that, participants will be allowed an ad libitum intake of standard meals. Each meal will be weighed before and after it is consumed, with the amount of food ingested being calculated.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age between 18-50 years
  • Males and females
  • Apparently healthy
  • Fasting triglyceride (TG) < 2.5 mmol/L or 222 mg/dl at the time of screening.
  • Body mass index (BMI) in normal range (18.5-24.9).
  • Stable weight for at least 3 months

Exclusion criteria

  • Consumption of lipid-lowering drugs or any medication that might affect appetite.
  • Consumption of any supplement that may affect lipid metabolism or appetite on a regular basis for the past month.
  • Regular consumption of two or more fish meals a week over the previous month.
  • A history of diabetes, gastrointestinal , liver disease, congestive heart failure, stroke, myocardial infarction, coronary artery bypass graft or established atherosclerotic disease.
  • Current smokers
  • Pregnant , breastfeeding, postmenopausal or suffer from polycystic ovary syndrome (PCOS)
  • Athlete
  • Being on a diet or lifestyle changes for the past month.

Treatment and study plan

Coconut oil

Dietary Supplement

Coconut oil will be given to each participant in the amount of 40 g, which will be incorporated into biscuits.

Palm oil

Dietary Supplement

Palm oil will be given to each participant in the amount of 40 g, which will be incorporated into biscuits.

Primary outcomes

  1. Anthropometric measurements ( Height)

    Time frame: baseline, pre-intervention, 1 day for each participant /during 3 months

    Standing height, without footwear, will be taken using stadiometer to the nearest 5mm

  2. Anthropometric measurements (Weight)

    Time frame: baseline, pre-intervention, 1 day for each participant /during 3 months

    Bioelectrical impedance will be used to determine body weight

  3. Anthropometric measurements (waist circumference)

    Time frame: baseline, pre-intervention, 1 day for each participant /during 3 months

    Waist circumference (WC) will be measured at the midway between the lowest ribs and the iliac crest using a standard tape to the nearest 1 cm

  4. Anthropometric measurements (percentage body fat)

    Time frame: baseline, pre-intervention,1 day for each participant /during 3 months

    Bioelectrical impedance will be used to determine body composition

  5. Biochemical measurements (Total cholesterol (TC))

    Time frame: After the intervention / up to 3 months from collecting the samples

    Up to 6 hours

  6. Biochemical measurements (Low density lipoprotein cholesterol (LDL))

    Time frame: Up to 6 hours

    Low-density lipoprotein cholesterol test will be performed after an overnight fast and 2, 4, and 6 hours after eating the meals

  7. Biochemical measurements ( High density lipoprotein cholesterol (HDL))

    Time frame: Up to 6 hours

    High-density lipoprotein cholesterol test will be performed after an overnight fast and 2, 4, and 6 hours after eating the meals

  8. Biochemical measurements (Triglyceride (TG))

    Time frame: Up to 6 hours

    Triglyceride test will be performed after an overnight fast and 2, 4, and 6 hours after eating the meals

  9. Dietary intake (3-days food record)

    Time frame: one day

    Participants will be asked to fill out a food record to track changes in their (intake) appetite

Sponsors and collaborators

Lead sponsor

University of Jordan

Other

Registry information

Official study title

Comparison of the Effect of Medium-Chain Fatty Acids and Long-Chain Fatty Acids on Postprandial Appetite and Lipemia

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Sep 14, 2022
Registry last updated
Aug 29, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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