Skip to main content
OpenTrials
Completed

NCT Number: NCT07078474

Comparison of Skin Condition After Hyaluronic Acid Application on Dry vs. Moist Skin

This study aims to compare the effects of two different methods of applying hyaluronic acid (HA) on skin parameters in healthy individuals. HA is a widely used ingredient in skincare products due to its hydrating properties. However, it is unclear whether applying HA to dry or pre-moistened skin provides better results in terms of skin hydration and texture.

In this non-invasive, interventional trial, 23 healthy volunteers aged 18 to 50 will be randomly assigned to two groups. One group will apply HA to dry skin, while the other will apply HA to moistened skin. Skin parameters will be measured before and after the intervention to assess hydration, transepidermal water loss, and overall skin condition.

The aim is to determine the optimal method of HA application that maximizes its effectiveness in improving skin quality. Participants may benefit from improved skin hydration and increased awareness of the best application method for their skin type. No significant risks are expected from participation.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Skin Hydration Hyaluronic Acid

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Split School of Medicine

Split, Split-Dalmatia County, 21000, Croatia

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy individuals aged 18 to 50 years
  • Willingness to apply the product daily for 3 weeks
  • Ability to attend all scheduled skin assessments (baseline + weekly)
  • Provided written informed consent

Exclusion criteria

  • Known allergy or sensitivity to hyaluronic acid or any component of the product
  • Active skin diseases or dermatological conditions in the facial area
  • Use of systemic or topical corticosteroids or retinoids within 4 weeks prior to study
  • Pregnancy or breastfeeding
  • Participation in another clinical trial within the past 30 days

Treatment and study plan

Topical Hyaluronic Acid

Other

Hyaluronic acid was applied topically to the facial skin of healthy participants once daily for a period of 3 weeks. Two application methods were used: on dry skin and on pre-moistened skin. Skin measurements were performed at baseline and after each week of intervention (Week 1, Week 2, and Week 3) to assess hydration and other skin parameters.

Primary outcomes

  1. Change in skin hydration level

    Time frame: Baseline, Week 1, Week 2, Week 3

    Skin hydration will be measured at four time points using a corneometer or comparable non-invasive skin analysis device. Measurements will be taken before the intervention (baseline) and at the end of each week to assess cumulative and comparative effects of hyaluronic acid application.

Sponsors and collaborators

Lead sponsor

University of Split, School of Medicine

Other

Registry information

Official study title

Comparison of Different Methods of Hyaluronic Acid Application on Skin Parameters

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jul 22, 2025
Registry last updated
Jul 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.