Comparison of Single and Repeated Dose of Vaginal Misoprostol for the Treatment of Early Pregnancy Failure

A randomised controlled trial assessing the efficacy of single versus repeated dose of vaginal misoprostol for the treatment of early pregnancy failure.

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Key information

Conditions

Abortion, Missed Abortion, Spontaneous Female Urogenital Diseases and Pregnancy Complications Pregnancy Complications Urogenital Diseases

Age range

18 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Wolfson Medical Center

Holon, Israel

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Women with early pregnancy failure, defined as missed abortion or blighted ovum, seeking medical treatment with misoprostol.
Age equal or greater than 18 years
Gestational age less than 12 complete weeks.

Exclusion criteria

Complete, incomplete, inevitable, or septic abortion.
Hemodynamically unstable patients.
Misoprostol sensitivity or contraindication.
Multifetal pregnancies.

Treatment and study plan

Misoprostol

Drug

Other names: Cytotec

Primary outcomes

Complete abortion (Endometrial thickness of less than 15 mm, as assessed by trans-vaginal ultrasound.)

Time frame: Day 8 from first misoprostol dose

Endometrial thickness of less than 15 mm, as assessed by trans-vaginal ultrasound.

Sponsors and collaborators

Lead sponsor

Wolfson Medical Center

Other Gov

Registry information

Official study title

Comparison of Single and Repeated Dose of Vaginal Misoprostol for the Treatment of Early Pregnancy Failure - a Randomized Clinical Trial

Important dates

Study start: 2015
Primary completion: 2016
Study completion: 2016
First posted: Aug 5, 2015
Registry last updated: Nov 1, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed