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OpenTrials
Completed

NCT Number: NCT07445321

Comparison of Rate and Amount of Orthodontic Space Closure

The goal of this clinical trial is to compare rate and amount of space closure among fresh vs healed extraction sites during fixed orthodontic treatment in patients with all first premolar's extraction Primary outcome measure is to calculate rate and amount of space closure between fresh vs healed as well as maxilla and mandible.

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Key information

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Dr Ishrat ul Ebad Khan Institute of Oral Health Sciences

Karachi, Sindh, 75300, Pakistan

About this study

The mandibular and maxillary arches of 34 patients will be included whose treatment plan decision was the extraction of all first premolars. Due to the split mouth approach, patients' maxillary and mandibular arches are randomly subdivided into two groups (right and left sides). First premolar extraction spaces in Group 1 will be closed once they have healed (6 week), while first premolar extraction spaces in Group 2 will be closed immediately after extraction. Both the upper and lower extraction spaces will be closed using coil springs (magnitude of force 30g per side). We'll specify the following time intervals: T1: Immediately prior to space closure; T2: 1 month after initial space closure; T3: 2 months after initial space closure T3: 3 months after initial space closure. Records will include measuring the rate and amount of space closure through Vernier calipers on dental cast as well as intraorally and will be evaluated at each time point.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18-35 years.
  • Patients undergoing fixed appliance treatment.
  • Good oral hygiene and periodontal support.
  • Patients with all first premolar's extraction treatment plan.
  • Atraumatic extraction.

Exclusion criteria

  • History of previous orthodontic treatment
  • Systemic diseases like diabetes, hypertension etc
  • Any bone pathology or taking medicines like bisphosphonates
  • Patients with clefts or any syndromic condition.
  • Patients with old extraction socket.

Treatment and study plan

Space Closure

Procedure

Space Closure in fresh vs healed extraction socket

Other names: Extraction

Primary outcomes

  1. To compare rate of space closure among fresh vs healed extraction sites during fixed orthodontic treatment in patients with all first premolar's extraction.

    Time frame: four time points are taken. T0: Baseline, T1: One month, T2: Two months, T3: Three months

    This study will be useful in making the timely decision for extraction of premolars and estimation of orthodontic treatment duration as well.

Secondary outcomes

  1. To compare amount of space closure among fresh vs healed extraction sites during fixed orthodontic treatment in patients with all first premolar's extraction.

    Time frame: Space closure at T3 is subtracted from T0

    Total space closure

Sponsors and collaborators

Lead sponsor

Dow University of Health Sciences

Other

Registry information

Official study title

Comparison of Rate and Amount of Orthodontic Space Closure After All First Premolars Extraction in Healed vs Fresh Extraction Sites. A Randomized Clinical Trial.

Acronym: Premolar

Important dates

Study start
2023
Primary completion
2023
Study completion
2024
First posted
Mar 3, 2026
Registry last updated
Mar 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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