Skip to main content
OpenTrials
Completed

NCT Number: NCT07389551

Comparison of Pregabalin Versus Gabapentin as Pre-emptive Analgesic

There are extensive gaps in the local data considering pregabalin versus gabapentin as pre-emptive analgesics in patients undergoing orthopedic surgeries under spinal anesthesia. Therefore, the current study was planned with the objective of comparing pregabalin versus gabapentin as pre-emptive analgesics in patients undergoing orthopedic surgeries under spinal anesthesia.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Orthopedic Surgery

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Victoria Hospital/Qaid-e-Azam Medical College

Bahawalpur, Punjab Province, 63100, Pakistan

About this study

Since postoperative pain in orthopedic surgery, whether neuropathic or nociceptive, presents a significant challenge for both surgeons and patients, knowing the more effective gabapentinoid as a pre-emptive analgesic would help clinicians to offer prolonged timing of first rescue analgesia and less opioid consumption.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Either gender
  • Aged 20-60 years
  • Undergoing lower limb orthopedic surgeries under spinal anesthesia

Exclusion criteria

  • Patients with a previous history of spine interventions, including surgery or injections (transforaminal, epidural, or facetal) for pain relief
  • Patients under any sort of pain modulation therapy, like transcutaneous electrical nerve stimulation
  • Patients had a long-term history of any analgesia use
  • Those with psychiatric disorders, alcohol/drug dependence, hepatic, renal, cardiac, or pulmonary abnormalities,
  • With a history of allergies to gabapentinoids

Treatment and study plan

Gabapentin

Drug

Patients were given a single oral dose of gabapentin 300 mg, with 30 ml of water, one hour prior to administration of spinal anesthesia.

Pregabalin

Drug

Patients received pregabalin 150 mg as a single oral dose, with 30 ml of water, one hour prior to administration of spinal anesthesia.

Primary outcomes

  1. Pain severity

    Time frame: 24 hours

    The severity of pain was analyzed on the visual analogue scale (VAS), with a lower score labelling the effectiveness of the treatment.

  2. Analgesia duration

    Time frame: 24 hours

    The duration of analgesia was measured from awakening to the need of rescue analgesia, when a pain score was more than 3 on VAS.

Sponsors and collaborators

Lead sponsor

Muhammad Aamir Latif

Other

Registry information

Official study title

Comparison of Pregabalin Versus Gabapentin as Pre-emptive Analgesic in Patients Undergoing Orthopedic Surgeries Under Spinal Anesthesia

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Feb 5, 2026
Registry last updated
Feb 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.