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OpenTrials
Completed

NCT Number: NCT05643040

Comparison of Perioperative Analgesic Efficacy of Femoral Nerve Block, Adductor Canal Block and 4in1 Block

Central neuraxial and regional anesthesia and analgesia techniques significantly reduce perioperative morbidity and mortality in the knee and below-knee surgeries.Nerve blocks appear to have better analgesic efficacy compared to placebo or patient-controlled analgesia (PCA). In addition, opioid-related side effects such as postoperative nausea, vomiting, pruritus, sedation, and respiratory depression are less. Therefore, interest in regional blocks such as femoral, sciatic, adductor, combined femoral, and sciatic is increasing. The knee joint is innervated by various nerves (genicular nerves) from the femoral, obturator, and sciatic nerves, and a comprehensive but simple technique is needed for postoperative analgesia. Complete and comprehensive postoperative analgesia was possible with this block, a simple single injection technique. The aim of our study is to evaluate the intraoperative analgesia efficacy of femoral, adductor canal block, and 4in1 block in patients who will undergo knee surgery.

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Key information

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Medical Science, Yıldırım Beyazıt Training and Research Hospital

Ankara, 06000, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients between the ages of >18
  • undergone knee surgery
  • American Society of Anesthesiologists (ASA) classification I-III group.

Exclusion criteria

  • Patients who do not want to participate in the study coagulopathy peripheral neuropathy local anesthetic drug allergy chronic opioid users anticoagulant users pregnant patients

Treatment and study plan

Femoral nerve block

Other

To evaluate the intraoperative analgesia effectiveness of femoral block in patients who will have knee surgery.

Adductor canal block

Other

To evaluate the intraoperative analgesia effectiveness of adductor canal block in patients who will have knee surgery.

4in1 block

Other

To evaluate the intraoperative analgesia effectiveness of 4in1 block in patients who will have knee surgery.

Primary outcomes

  1. intraoperative analgesia efficacy

    Time frame: perioperative period

    The aim of our study is to evaluate the intraoperative analgesia efficacy of femoral, adductor canal block and 4in1 block in patients who will undergo knee surgery.

Secondary outcomes

  1. postoperative analgesia efficacy

    Time frame: perioperative period

    The aim of our study is to evaluate the postoperative analgesia efficacy of femoral, adductor canal block and 4in1 block in patients who will undergo knee surgery.

Sponsors and collaborators

Lead sponsor

Diskapi Yildirim Beyazit Education and Research Hospital

Other Gov

Registry information

Official study title

Comparison of Perioperative Analgesic Efficacy in Patients Who Had Femoral Nerve Block, Adductor Canal Block and 4in1 Block Applied in Knee Surgery

Important dates

Study start
2022
Primary completion
2025
Study completion
2025
First posted
Dec 8, 2022
Registry last updated
Jul 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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