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OpenTrials
Completed

NCT Number: NCT05635383

REBOUND PAIN AFTER PERIPHERAL NERVE BLOCKS

In recent years, the use of regional anesthesia techniques as part of multimodal analgesia strategies to maximize pain control in patients has reduced opioid requirements and promoted early mobility and rehabilitation in the perioperative period. Regional anesthesia has benefits, mainly peripheral nerve blocks (PNB), muscle relaxation, and postoperative analgesia, thus allowing for control of postoperative pain and early discharge from the hospital. In addition, using PNB techniques provides:

Hemodynamic stability. Reduced need for a post-anesthetic care unit (PACU). Reduced unplanned hospitalization for pain control. Less airway management. Reduced incidence of opioid-related adverse events. Greater patient satisfaction

The main feature of rebound pain is that it is severe pain, within 8-24 hours after PNB. It usually remains severe for 2-6 hours, but the subsequent pain trajectory is consistent with the recovery process expected at surgical intervention. Therefore, rebound pain is temporary and different from persistent post-surgical pain (PPSP).

Rebound pain often occurs at night. However, this is probably related to the 8 to 12-hour duration of most single-injection PNBs and the completion of most elective surgeries during daylight hours.

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Key information

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey (Türkiye)

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About this study

This study aims to reveal the rebound pain profile, determine the risk factors, and contribute to developing strategies that can prevent rebound pain.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged >18 years who underwent orthopedic surgery with the peripheral nerve block

Exclusion criteria

  • Patients who did not want to participate in the study
  • dementia
  • severe psychiatric or cognitive dysfunction
  • coagulopathy
  • neuropathic disorder
  • local anesthetic allergy
  • serious heart-lung disease
  • chronic opioid use

Treatment and study plan

Peripheral nerve block

Other

Observation of rebound pain after peripheral nerve block application

Primary outcomes

  1. incidence of rebound pain

    Time frame: perioperative period

    Rebound pain-defined as transient acute postoperative pain within 12-24hrs that ensues following resolution of sensory blocked.

Secondary outcomes

  1. rebound pain risk factors

    Time frame: perioperative period

    such as age, gender, and presence of preoperative pain.

Sponsors and collaborators

Lead sponsor

Diskapi Yildirim Beyazit Education and Research Hospital

Other Gov

Registry information

Official study title

Investigation of the Frequency and Causes of Rebound Pain Phenomenon After Peripheral Nerve Blocks

Important dates

Study start
2022
Primary completion
2024
Study completion
2024
First posted
Dec 2, 2022
Registry last updated
Mar 28, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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