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NCT Number: NCT07705763

Comparison of Ketorolac Tromethamine 0.5%-Soaked Bandage Contact Lenses Versus Non-Medicated Bandage Contact Lenses on Postoperative Pain Control After Photorefractive Keratectomy

Photorefractive keratectomy (PRK) is a well-established surface ablation procedure for the correction of refractive errors. Despite excellent visual and refractive outcomes, postoperative pain remains a significant concern, particularly during the first few days following surgery. This pain is primarily related to corneal epithelial removal, exposure of subepithelial nerve endings, and the subsequent inflammatory response. Effective pain management is therefore essential to enhance patient comfort, improve compliance with postoperative care, and increase overall surgical satisfaction. Therefore we will compare postoperative pain levels in patients undergoing PRK using ketorolac tromethamine 0.5%-soaked bandage contact lenses versus non-medicated bandage contact lenses.

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Key information

Conditions

Refraction Error Eye Diseases Photorefractive Keratectomy Refractive Errors

Age range

21 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Madina Teaching Hospital Faisalabad

Faisalābad, Punjab Province, 38000, Pakistan

Location contact

Prof Dr Muhammad Zahid Siddiq, MBBS, FCPS

CONTACT

[email protected]

+923217878075

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants selected to undergo photorefractive keratectomy for correction of refractive error after complete workup.
  • Participants willing to participate in the study after detailed explanation of the research purpose.

Exclusion criteria

  • Known hypersensitivity to NSAIDs or ketorolac.
  • Presence of any systemic diseases affecting wound healing.

Treatment and study plan

Ketorolac Tromethamine 0.5%-Soaked Bandage Contact Lenses

Device

Soaking Bandage Contact Lenses in ketorolac prior to application may provide sustained drug release at the ocular surface, thereby enhancing postoperative pain control while reducing the need for repeated topical administration.Recent studies have suggested that ketorolac-soaked Bandage Contact Lenses may significantly reduce pain following Photorefractive Keratectomy without adversely affecting epithelial healing

Contact Bandage Lenses

Device

Bandage contact lenses (BCLs) are routinely used after PRK to protect the corneal surface, reduce mechanical irritation from blinking, and promote epithelial healing

Primary outcomes

  1. Postoperative Pain

    Time frame: 72 hours

    Postoperative pain assessed using a standardized pain scoring system (e.g., Visual Analogue Scale) at 6, 24, 48, and 72 hours postoperatively.

Secondary outcomes

  1. Epithelial Healing

    Time frame: 72 hours

    Time for epithelial healing

Study contacts

Contact information is provided by the study sponsor or research team.

Dr Hassan Abbas, MBBS

CONTACT

[email protected]

+923076781178

Sponsors and collaborators

Lead sponsor

Madina Teaching Hospital Faisalabad

Other

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jul 15, 2026
Registry last updated
Jul 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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