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OpenTrials
Completed

NCT Number: NCT01774006

Comparison of Individual Culture and Group Culture of Preimplantation Embryos in Human IVF Treatments

Prospective randomized comparison of two widely used in vitro culture system in human IVF treatments. In vitro fertilized oocytes and embryos are cultured in individual culture media droplets using conventional petridish or in group culture using WOW (well of the well) petridish.

Primary outcome: implantation and pregnancy rates Secondary outcome: fertilization rate and embryo quality

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Key information

Conditions

Other Complications Associated With Artificial Fertilization

Age range

18 year–45 year

Sex eligibility

Female

Study type

Observational

Primary location

Semmelweis University First Department of Obstetrics and Gynecology

Budapest, 1088, Hungary

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Infertile patients entering in vitro fertilization treatment
  • at least 1 oocyte collected

Exclusion criteria

  • no oocytes collected

Treatment and study plan

individual embryo culture or group culture

Other

Embryos cultured in a 25 microliter droplet of culture media individually in a conventional petridish or in groups of 2-10 embryos in a Well-of-the-Well petridish

Primary outcomes

  1. Clinical pregnancy rate

    Time frame: 4 weeks after the embryo transfer

    Number of clinical pregnancies (/No. of embryo transfers)

  2. Implantation rate

    Time frame: 4 weeks after embryo transfer

    Number of embryos implanted (/number of embryos transferred)

Secondary outcomes

  1. Fertilization rate

    Time frame: 18 hours after sperm injection

    Number of oocytes fertilized. (only in intracytoplasmic sperm injection cycles)

  2. Embryo quality

    Time frame: 36 and 72 hours after fertilization

    Number and quality of blastomeres, amount of fragmentation embryo grade

Other outcomes

  1. Time needed for evaluation of zygotes and embryos

    Time frame: 18, 24, 36 and 72 hours after fertilization

Sponsors and collaborators

Lead sponsor

Semmelweis University

Other

Registry information

Acronym: GroupCulture

Important dates

Study start
2012
Primary completion
2015
Study completion
2015
First posted
Jan 23, 2013
Registry last updated
Sep 2, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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