Polscope Sperm: A Non-invasive Method to Assess DNA Damage in Individual Sperm

The purpose of this study is to find a non-invasive way to discover DNA (deoxyribonucleic acid, which is the genetic material inside your cells) alterations in the sperm's head, in the near future leading us to choose the "good sperm" in a simplified manner. This could then increase chances of a successful in-vitro fertilization (IVF) treatment when there are sperm abnormalities.

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Key information

Conditions

DNA Damage Other Complications Associated With Artificial Fertilization

Age range

18 year–60 year

Sex eligibility

Male

Study type

Observational

Primary location

University of South Florida South Tampa Center

Tampa, Florida, 33606, United States

About this study

If you take part in this study,

Your physician is asking you to provide a semen sample as you already would. The sample will be taken to the IVF lab which would occur if you were not involved in this research. The part that would be thrown away is then further analyzed under a polarized light microscope. The sample is exposed to ultraviolet (UV) light for a period of 20 minutes after which it is analyzed under the microscope again, looking for any changes when compared the sample that was not exposed to UV light. The sample is then discarded.
Your name will be removed from the sample after the regular semen analysis is done; therefore there will be no way of associating the research results with you. No information will be needed from you and you will not be contacted in the future regarding this research.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age 18-60 years
provide informed consent
Already providing a semen sample as routine therapy in IVF

Exclusion criteria

-unable to provide informed consent

Sponsors and collaborators

Lead sponsor

University of South Florida

Other

Registry information

Official study title

A Non-invasive Method to Assess DNA Damage in Individual Sperm

Important dates

Study start: 2008
Primary completion: 2012
Study completion: 2012
First posted: Oct 28, 2011
Registry last updated: Aug 24, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed