Kocaeli University
Kocaeli, 41350, Turkey (Türkiye)
NCT Number: NCT06493162
Flow-Controlled Ventilation is designed to ventilate the patient with constant flows during both inspiration and expiration. During inspiration, the pressure rises linearly from a set positive end-expiratory pressure (PEEP) to a set positive inspiratory pressure (PIP), and then falls linearly from PIP to end-expiratory pressure (EEP) during expiration. There are no flow interruptions during the Flow-Controlled Ventilation cycle, and the rate of change of pressure and volume in the lungs is equal, allowing for higher tidal volumes at lower pressures. The user sets the inspiratory flow rate and the ratio of inspiratory to expiratory time, providing full control over the ventilation cycle. However, this results in two unusual features: During inspiration, the ventilator creates positive pressure to direct gas into the patient's lungs through the endotracheal tube (ETT). When the intratracheal pressure (airway pressure) reaches the set PIP value, the ventilator switches from inspiration to expiration. By reversing the flow, it utilizes the Bernoulli effect to create negative pressure, facilitating expiration. Despite the presence of negative pressure on the ventilator side, the pressure in the patient's airway remains positive at all times.
Volume-controlled ventilation is a mode that is volume-controlled, time-cycled, time-triggered, and pressure-limited. In volume-controlled ventilation, high pressures are sometimes necessary to reach the target tidal volume. This can lead to barotrauma, atelectrauma, and volutrauma in the lungs. Therefore, to avoid high pressures, low tidal volume ventilation is preferred.
For Microscopic Laryngeal Surgeries, patients are intubated with a small sized endotracheal tube which results with higher pressures. We think that flow controlled ventilation will improve the ventilation during the surgery with lower pressures.
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Notify Me18 year–75 year
All sexes
Interventional
Not applicable
Kocaeli, 41350, Turkey (Türkiye)
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Patients will be intubated with 5mm sized endotracheal tube for microscopic laryngeal surgery
Patients in FCV group will be ventilated with flow controlled ventilation mode
Patients in VCV group will be ventilated with volume controlled ventilation mode
Time frame: 10 minutes interval after the intubation during the surgery
Peak inspiratory pressure
Time frame: 10 minutes interval after the intubation during the surgery
Respiratory rate
Time frame: 10 minutes interval after the intubation during the surgery
Tidal volume
Time frame: 10 minutes interval after the intubation during the surgery
Dynamic compliance (ventilator calculates: Cdyn = tidal volume/(PIP - PEEP)
Time frame: 10 minutes interval after the intubation during the surgery
Resistance (ventilator calculates: dividing the [peak pressure minus the plateau pressure] by the flowrate in litres per second)
Time frame: 10 minutes interval after the intubation during the surgery
Heart rate
Time frame: 10 minutes interval after the intubation during the surgery
Mean blood pressure
Time frame: 10 minutes interval after the intubation during the surgery
Oxygen saturation
Kocaeli University
Other
Comparison of Flow Controlled Ventilation and Volume Controlled Ventilation in Microscopic Laryngeal Surgeries, a Randomized Controlled Trial
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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