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OpenTrials
Completed

NCT Number: NCT07165873

Comparison of ESP, SAP and SPSIP Blocks on VATS'

This study aimed to compare erector spinae plane block (ESPB), serratus anterior plane block (SAPB), and serratus posterior superior intercostal plane block (SPSIPB) to determine the most suitable technique for maintaining postoperative analgesia in video-assisted thoracoscopic surgeries (VATS).

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sivas Cumhuriyet University

Sivas, 58000, Turkey (Türkiye)

About this study

Patients were randomly allocated into three groups: ESPB, SAPB, and SPSIPB. All patients received postoperative paracetamol and dexketoprofen, and intravenous tramadol hydrochloride was administered via patient-controlled analgesia. Postoperative static and dynamic VAS scores, total tramadol consumption, side effects, and the need for additional analgesia were monitored and recorded at regular intervals. Primary outcome was VAS scores and secondary outcome was total tramadol consumption.

Block Techniques

All blocks were performed following surgical closure, prior to extubation, with the patient in lateral decubitus and the skin prepared with 10% povidone-iodine.

ESPB was performed in 15 patients. An ultrasound (USG) probe was placed in a sagittal orientation at the T5 level, 3 cm lateral to the midline, to visualize the transverse process. The trapezius, rhomboid major, and erector spinae muscles were identified. Using an in-plane technique, a needle was advanced cranio-caudally through these muscles until it reached the transverse process. After negative aspiration, 30 mL of 0.25% bupivacaine was injected deep to the erector spinae muscle.

SAPB: The latissimus dorsi and serratus anterior muscles were identified at the midaxillary line at the 4th-5th rib level in a longitudinal parasagittal orientation. A needle was advanced from caudal to cranial using an in-plane approach, first targeting the plane between the latissimus dorsi and serratus anterior, and then deep to the serratus anterior. After negative aspiration, 10 mL was injected into the superficial plane and 20 mL into the deep plane, for a total of 30 mL of 0.25% bupivacaine.

SPSIPB: The USG probe was placed 2-3 cm medial to the scapular spine to visualize the trapezius, rhomboid major, and serratus posterior superior muscles. At the level of the 2nd-3rd ribs, a needle was advanced into the plane between the serratus posterior superior muscle and the rib. After confirming negative aspiration, 30 mL of 0.25% bupivacaine was injected.

All blocks were performed unilaterally, targeting the surgical hemithorax.

Postoperative Analgesia and Assessments

Twenty minutes before extubation, all patients received 1 g IV paracetamol and 50 mg IV dexketoprofen. In the recovery room, patient-controlled analgesia (PCA) with IV tramadol hydrochloride was initiated (4 mg/mL concentration, 10 mg bolus, 20-minute lockout, maximum 3 boluses/hour).

Postoperative VAS scores (static at rest and dynamic during movement or coughing) were recorded at 0, 1, 6, 12, 18, and 24 hours. The first VAS assessment (0 hour) was performed when the patient achieved an Aldrete score of 9. If VAS ≥ 4, an additional 1 g IV paracetamol (maximum 3 g/day) was administered. Additional analgesic consumption was recorded. Side effects such as nausea, vomiting, and pruritus were documented.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Forty-five adult patients scheduled for elective wedge resection or biopsy under VATS, classified as American Society of Anesthesiologists (ASA) physical status I-III, were enrolled after providing written informed consent.

Exclusion criteria

  • ASA class IV or higher,
  • morbid obesity (BMI > 40 kg/m²),
  • body weight ≤ 50 kg,
  • skin infection at the block site,
  • refusal to participate,
  • inability to cooperate during postoperative pain assessment,
  • conversion to open surgery,
  • preexisting pain,
  • known allergy to any study medication,
  • coagulopathy.

Treatment and study plan

Erector Spinae Plane Block

Procedure

30 mL of 0.25% bupivacaine was injected deep to the erector spinae muscle.

Other names: ESP block

Serratus anterior plane block (SAP)

Procedure

10 mL was injected into the superficial plane and 20 mL into the deep plane, for a total of 30 mL of 0.25% bupivacaine.

Other names: SAP block

Serratus Posterior Superior Intercostal Plane Block

Procedure

30 mL of 0.25% bupivacaine was injected into the plane between the serratus posterior superior muscle and the rib.

Other names: spsip block

Primary outcomes

  1. Visual analogue scale (VAS) score

    Time frame: postoperative 24 hours

    The Visual Analogue Scale (VAS) measures pain intensity. The VAS consists of a 10 cm line, with two end points representing 0 ('no pain') and 10 ('pain as bad as it could possibly be').

Secondary outcomes

  1. Total tramadol consumption

    Time frame: postoperative 24 hours

    Postoperative total analgesic (tramadol) need was recorded as "milligram" in unit.

Sponsors and collaborators

Lead sponsor

Cumhuriyet University

Other

Registry information

Official study title

Comparison of the Analgesic Efficacy of Erector Spinae Plane Block, Serratus Anterior Plane Block, and Serratus Posterior Superior Intercostal Plane Block on Postoperative Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgery

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Sep 10, 2025
Registry last updated
Sep 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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