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NCT Number: NCT07723326

Comparison of Electrocautery and Scalpel Blade Incisions of Impacted Mandibular Third Molars

This randomized controlled trial aims to compare electrocautery and scalpel blade incisions during surgical extraction of impacted mandibular third molars. The study will evaluate postoperative pain, intraoperative blood loss, and wound healing in patients undergoing third molar surgery. A total of 78 participants will be randomly allocated in a 1:1 ratio to receive either a scalpel blade incision or an electrocautery incision under standardized surgical conditions.

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Key information

Age range

15 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Islamic International Dental Hospital

Islamabad, 44000, Pakistan

Location contact

Muhammad Usama, BDS/FCPS

CONTACT

[email protected]

+923325595484

Uzair Luqman, BDS/FCPS

PRINCIPAL_INVESTIGATOR

About this study

Surgical extraction of impacted mandibular third molars is one of the most common procedures in oral and maxillofacial surgery. The type of incision used may influence postoperative outcomes, including pain, bleeding, and wound healing. Electrocautery offers simultaneous cutting and coagulation, potentially reducing intraoperative blood loss and improving surgical visibility, whereas scalpel incisions produce precise tissue cuts without thermal injury.

This prospective, two-arm, parallel-group, randomized controlled trial will compare electrocautery and scalpel blade incisions in patients undergoing surgical extraction of impacted mandibular third molars. Seventy-eight participants will be randomly assigned to either Arm A (scalpel blade incision) or Arm B (electrocautery incision). All other surgical and perioperative variables, including local anesthesia, flap design, irrigation, suture material, and postoperative medications, will be standardized.

The primary outcome is postoperative pain assessed using a Visual Analogue Scale at 24 hours, 48 hours, and 7 days. Secondary outcomes include intraoperative blood loss and wound healing assessed using the Landry Wound Healing Index at 1 and 4 weeks. The findings of this study will provide evidence regarding the most appropriate incision technique for impacted mandibular third-molar surgery.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male and female patients.
  • Age 15 to 65 years.
  • Patients requiring surgical extraction of an impacted mandibular third molar. Patients classified as ASA I or ASA II.
  • Patients willing to provide written informed consent, or assent with parent/guardian permission where applicable, and attend scheduled follow-up visits

Exclusion criteria

  • * Patients with uncontrolled systemic disease or immuno-compromised status.
  • Patients with bleeding disorders or those taking anticoagulant/antiplatelet drugs that cannot be safely withheld according to physician advice.
  • Patients with pacemaker or implanted electrical cardiac device.
  • Pregnant or lactating patients.
  • Patients with acute infection, pericoronitis, facial space infection, or pus discharge at the surgical site at the time of surgery.
  • Patients requiring bilateral third-molar extraction in the same sitting.
  • Patients unwilling to participate or unable to return for follow-up.

Treatment and study plan

scalpel blade incision

Procedure

A sterile No. 15 stainless-steel scalpel blade will be used to make the mucoperiosteal flap incision during surgical extraction of the impacted mandibular third molar.

electrocautery incision

Procedure

A fine electrocautery electrode in cutting mode at a standardized effective power setting will be used to make the mucoperiosteal flap incision during surgical extraction of the impacted mandibular third molar.

Primary outcomes

  1. postoperative pain

    Time frame: 24 hours, 48 hours, and 7 days after surgery.

    Postoperative pain at the surgical site will be assessed using a 0-10 Visual Analogue Scale (VAS), where 0 indicates no pain and 10 indicates the worst imaginable pain

Secondary outcomes

  1. intraoperative blood loss

    Time frame: During surgery (from first incision to final suture).

    Total blood loss will be calculated as the increase in gauze weight plus the suction-canister volume after subtracting the recorded irrigation volume. Results will be reported in milliliters (mL).

  2. wound healing

    Time frame: 1 week and 4 weeks after surgery.

    Wound healing will be assessed using the Landry Wound Healing Index, scored from 1 (very poor) to 5 (excellent).

Study contacts

Contact information is provided by the study sponsor or research team.

Muhammad Usama, BDS/FCPS

CONTACT

[email protected]

+923325595484

Uzair Luqman, BDS/FCPS

CONTACT

[email protected]

+923215080354

Sponsors and collaborators

Lead sponsor

Riphah International University

Other

Registry information

Official study title

Comparison of Electrocautery and Scalpel Blade Incisions on Postoperative Pain, Intraoperative Blood Loss, and Wound Healing Following Surgical Extraction of Impacted Mandibular Third Molars: A Randomized Controlled Trial

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jul 23, 2026
Registry last updated
Jul 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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