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NCT Number: NCT06469346

Comparison of Eccentric Exercise and Static Stretching on Muscle Flexibility

Background: Muscle flexibility is a fundamental physical quality for body development, daily life and sports activities, and also for maintaining muscle quality during aging. Limited flexibility leads to an increased prevalence of musculoskeletal injury in general population and longer return to sports activities.

Among the existent strategies to increase muscle flexibility in sports training and physical rehabilitation, static stretching is commonly used by health and physical activity professionals. Its effectiveness in increasing flexibility has been widely demonstrated; however its effects on muscle strength and power remains controversial.

Therefore, eccentric resistance exercise has been proposed as an effective intervention for increasing muscle flexibility through structural changes on muscle architecture (pennation angle and fascicle length) with the additional benefit of resistance training on muscle strength and power. Nonetheless, its unknown if the increase in muscle flexibility through eccentric resistance exercise could be similar to what has been previously demonstrated with static stretching.

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Key information

Age range

18 year–35 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Universidad de La Frontera

Temuco, Cautín, 4780000, Chile

About this study

Hypothesis: The increase in hamstring flexibility after 6 weeks of eccentric resistance training in young males would be similar compared to 6 weeks static stretching training in the same population.

Goals: The primary aim of the study is to compare the effectiveness of 6 weeks eccentric resistance training vs 6 weeks static stretching training on hamstring flexibility in young males.

Specific Goals: Determine the effect of 6 weeks excentric exercise training and 6 weeks static stretching training on unilateral maximal isometric voluntary strength between both groups

To compare the effect of 6 weeks excentric exercise training and 6 weeks static stretching training in structural changes on muscle architecture (pennation angle, fascicle length and muscle thickness).

Methodology:

Study design: Forty two young males between 18 and 35 years will be divided into three groups: hamstring eccentric resistance training group (EEG, n=14), hamstring static stretching group (SSG, n=14) and control group (CG, n=14). Volunteers of eccentric resistance training group will be subjected to 6 weeks of Nordic hamstring exercise (3x/wk), while volunteers of static stretching group will be subjected to 6 weeks of hamstring passive static stretching (3x/wk). Control group will not attend any type of intervention. Before and after 6 weeks of training, Knee Extension Angle and Sit and Reach test will be performed for measuring hamstring flexibility. Unilateral Hamstring Isometric Maximal Voluntary Strength will be determined by load cell force transducer, and pennation angle, fascicle length and muscle thickness of Long Head Biceps Femoris will be conducted through muscle ultrasonography

Study parameters/endpoint:

The main study endpoint is the increase in hamstring flexibility assessed with Knee Extension Angle and Sit and Reach Test.

Secondary endpoints include Unilateral Hamstring Isometric Maximal Voluntary Strength (IMVS) and Architectural changes in Long Head Biceps Femoris muscle.

Other parameters include age, body weight, body height, body mass index (BMI), level of physical activity.

Expected results: With the proposed project, the investigators expect that eccentric exercise training will increase hamstring muscle flexibility at similar level compared with static stretching training. The findings will define the potential of eccentric exercise training on muscle flexibility in healthy participants. These results could expand the benefits of this type of exercise training focused on being included in populations with limited mobility such as elderly and injured populations

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Masculine University students between 18 and 35 years old
  • Physically Inactive considering physical activity recommendations from World Health Organization
  • Bilateral hamstring muscle stiffness defined as <160° in passive Knee Extension Angle Test
  • Body Max Index 18,5 < BMI < 24,9 kg/m2

Exclusion criteria

  • Lower back and lower limb (hip, thigh, knee, ankle) musculoskeletal injury in the last 12 months.
  • Hamstring injury (strain, tendinopathy, tendon avulsion) previously during the period of life
  • Dietary anabolic supplements consumption
  • Musculoskeletal, cardiovascular, respiratory o similar health condition that limits participation on physical activity programs
  • Regular resistance training (2 or more times per week, carrying out progressive training) in the previous 6 months
  • Smoker (1 cigarette per day)

Treatment and study plan

Nordic Hamstring Eccentric Exercise Training

Other

Warm up: stationary bycicle at 50 watts and 60 bpm Mobility exercises for hip and knee joint

Nordic eccentric exercise protocol:

  • Week 1: 2 sets x 5 repetitions
  • Week 2: 2 sets x 6 repetitions
  • Week 3: 3 sets x 6 repetitions
  • Week 4-6: 3 sets x 8 repetitions

Passive Hamstring Static Stretching Training

Other

Warm up: stationary bycicle at 50 watts and 60 bpm Mobility exercises for hip and knee joint

  • Week 1-2: 1 set x 2 repetitions of 30 seconds
  • Week 3: 1 set x 3 repetitions of 30 seconds
  • Week 4-6: 1 set x 3 reps of 40 seconds

Control Group

Other

No intervention

Primary outcomes

  1. Knee Extension Angle

    Time frame: Before and after 6 weeks of training

    The degree changes in passive knee extension will be assessed using Passive Knee Extension Angle Test after intervention

  2. Sit-and-Reach

    Time frame: Before and after 6 weeks of training

    The distance (in centimeters) of change on functional posterior chain flexibility will be obtained in Sit-and-Reach Test after intervention

Secondary outcomes

  1. Maximal Isometric Voluntary Strength

    Time frame: Before and after 6 weeks of training

    Change in unilateral isometric hamstring strength will be evaluated with load cell force transducer after intervention

  2. Long Head Biceps Femoris Pennation Angle

    Time frame: Before and after 6 weeks of training

    Change in pennation angle will be measured using muscular ultrasound after intervention

  3. Long Head Biceps Femoris Fascicle Length

    Time frame: Before and after 6 weeks of training

    Change in fascicle length will be measured using muscular ultrasound after intervention

  4. Long Head Biceps Femoris Muscle Thickness

    Time frame: Before and after 6 weeks of training

    Change in muscle thickness will be measured using muscular ultrasound after intervention

Sponsors and collaborators

Lead sponsor

Universidad de La Frontera

Other

Registry information

Official study title

Comparison Between Eccentric Exercise and Static Stretching on Hamstring Muscle Flexibility in Healthy Young

Acronym: COEESS

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Jun 21, 2024
Registry last updated
Jun 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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