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Completed

NCT Number: NCT05772832

COMPARISON OF DEXMEDETOMIDINE AND REMIFENTANIL FOR POSTOPERATIVE PAIN IN TRANSPHENOIDAL Pituitary SURGERY

In patients with pituitary adenoma scheduled for endoscopic transsphenoidal pituitary surgery, it was aimed to compare the efficacy of postoperative pain relief of a selective α-2 agonist "Dexmedetomidine" and the rapid and short-acting opioid "Remifentanil" using the "Numerical Rating Scale" (NRS) administered alongside propofol in perioperative maintenance anesthesia. .

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Key information

Conditions

Postoperative Pain Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Kocaeli

Kocaeli, IZMIT, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-65 years old
  • ASA-1 and ASA-2 patients

Exclusion criteria

  • Patients in need of postoperative intensive care

Treatment and study plan

Dexmedetomidine

Drug

Efficacy of dexmedetomidine on postoperative pain in patients undergoing transsphenoidal pituitary surgery

remifentanyl

Drug

Efficacy of remifentanyl on postoperative pain in patients undergoing transsphenoidal pituitary surgery

Primary outcomes

  1. postoperative pain scale

    Time frame: at post anesthesia care unit (T1)

    Comparison of postoperative Numerical Rating Scale(NRS) values of both study arms(min 0, max 10; 10 is unbearable pain )

  2. postoperative pain scale

    Time frame: 2 hours after surgery (T2)

    Comparison of postoperative Numerical Rating Scale(NRS) values of both study arms(min 0, max 10; 10 is unbearable pain )

  3. postoperative pain scale

    Time frame: 8 hours after surgery (T3)

    Comparison of postoperative Numerical Rating Scale(NRS) values of both study arms(min 0, max 10; 10 is unbearable pain )

  4. postoperative pain scale

    Time frame: 24 hours after surgery (T4)

    Comparison of postoperative Numerical Rating Scale(NRS) values of both study arms(min 0, max 10; 10 is unbearable pain )

Secondary outcomes

  1. need for analgesics

    Time frame: Additional analgesic drug requirements at post anesthesia care unit (T1)

    Comparison of whether there is a need for additional POSTOPERATIVE analgesic medication

  2. need for analgesics

    Time frame: Additional analgesic drug requirements at 2 hours after surgery (T2)

    Comparison of whether there is a need for additional POSTOPERATIVE analgesic medication

  3. need for analgesics

    Time frame: Additional analgesic drug requirements at 8 hours after surgery (T3)

    Comparison of whether there is a need for additional POSTOPERATIVE analgesic medication

  4. need for analgesics

    Time frame: Additional analgesic drug requirements at 24 hours after surgery (T4)

    Comparison of whether there is a need for additional POSTOPERATIVE analgesic medication

  5. Comparison of postoperative nausea-vomiting rate

    Time frame: at post anesthesia care unit (T1)

    Comparison of postoperative nausea-vomiting rate

  6. Comparison of postoperative nausea-vomiting rate

    Time frame: 2 hours after surgery (T2)

    Comparison of postoperative nausea-vomiting rate

  7. Comparison of postoperative nausea-vomiting rate

    Time frame: 8 hours after surgery (T3)

    Comparison of postoperative nausea-vomiting rate

  8. Comparison of postoperative nausea-vomiting rate

    Time frame: 24 hours after surgery (T4)

    Comparison of postoperative nausea-vomiting rate

Sponsors and collaborators

Lead sponsor

Kocaeli University

Other

Registry information

Important dates

Study start
2021
Primary completion
2022
Study completion
2023
First posted
Mar 16, 2023
Registry last updated
Aug 27, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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