Comparison of Dehydrated Human Amnion-Chorion and Type 1 Bovine Collagen Membranes for Guided Bone Regeneration

Forty-three patients requiring extraction of at least one tooth and delayed implant placement were randomly assigned to either an experimental or a control group. For both groups, demineralized freeze-dried bone allograft was used to graft the socket. For the control group, Type I bovine collagen was used as a membrane; for the experimental group, human amnion-chorion membrane was used. For both groups, the barrier membranes were left exposed, and no primary closure was achieved. Patients returned for implant placement after a mean healing period of 19.5 weeks, at which time a core bone biopsy specimen 2 mm in diameter was obtained for histomorphometric analyses. Clinical ridge dimensions were measured at the times of extraction and implant placement.

Inclusion criteria

.

Patients included in the study were required:

• Not to be completely edentulous.
• To have at least 1 tooth that could not be saved and for which extraction and delayed implant placement were planned

Exclusion criteria

Patients were excluded if they :

• Had received radiation therapy
• Were taking antiresorptive medication (i.e., bisphosphonate or denosumab)
• Had uncontrolled systemic disorders (such as uncontrolled diabetes, congestive heart failure, or acute odontogenic infections)
• Were smokers (more than 10 cigarettes per day)
• Were pregnant or breastfeeding.