Nutrition Intervention Center
Toronto, Ontario, M5S 3H2, Canada
Location status: Recruiting
Location contact
Alaa Awad, BSc
SUB_INVESTIGATOR
Amira Amr, PhD
CONTACT
Corrina Zhou, MSc
CONTACT
Courtney Leung, BSc
SUB_INVESTIGATOR
NCT Number: NCT06874400
The purpose of the Dairy vs Plant study is to compare the effects of dairy and plant-based alternative products on blood sugar regulation and nutrient quality in adolescents and older adults. We are inviting healthy, non-diabetic participants aged 14-18 and 60-75, both males and females to participate. The study will take place in the Nutrition Intervention Center located at the Department of Nutritional Sciences, University of Toronto St. George campus. Participants will be asked to come to the Nutrition Intervention Center on 3 separate occasions: once for an in-person screening lasting approximately 30min and 2 times for study visits lasting approximately 2.5 hrs each. The entire study will take a minimum of 2 weeks to complete. You will be asked to fast for 12hrs (overnight) prior to each study visit. You will also be instructed to maintain the same dietary and sleep patterns, refrain from exercise and alcohol consumption the days before the study visits. During these study visits, you will be asked to consume either a dairy or a plant-based alternative product, as well as a pizza meal. You will periodically fill out questionnaires rating your feelings and perceptions and provide blood samples through finger pricks and intravenously through forearm to measure blood sugar, insulin, hormones, and amino acids. You will be compensated for your time and travel expenses.
Interested in participating?
Request Info14 year–75 year
All sexes
Interventional
Not applicable
Toronto, Ontario, M5S 3H2, Canada
Location status: Recruiting
Alaa Awad, BSc
SUB_INVESTIGATOR
Amira Amr, PhD
CONTACT
Corrina Zhou, MSc
CONTACT
Courtney Leung, BSc
SUB_INVESTIGATOR
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
The dairy products that participants will be required to consume include: 1) Trial 1: 2% cow's milk; 2) Trial 2: dairy yogurt; 3) Trial 3: 2% cottage cheese; 4) Trial 4: 2% cow's milk; and 5) Trial 5: isolated whey protein beverage. Participants will only be enrolled in 1 of the 5 trials; as such, they will only consume the 1 dairy product in that trial.
Other names: Milk, yogurt, cheese, whey
The plant-based products that participants will be required to consume include: 1) Trial 1: soy beverage; 2) Trial 2: plant-based yogurt; 3) Trial 3: tofu; 4) Trial 4: 2% simulated milk; and 5) Trial 5: isolated soy protein beverage. Participants will only be enrolled in 1 of the 5 trials; as such, they will only consume the 1 plant-based alternative product in that trial.
Other names: soy beverage, plant-based yogurt, simulated milk, soy, tofu
Time frame: Over 145 minutes after treatment consumption at each session, for a total of 2 weekly sessions.
Blood glucose will be measured via finger-prick using a glucose meter at 0, 20, 35, 50, 65, 95, 125, and 145 minutes after treatment consumption.
Time frame: Over 145 minutes after treatment consumption at each session, for a total of 2 weekly sessions.
Insulin will be measured in the plasma through intravenous blood collection at 0, 35, 65, 95, 125, and 145 minutes after treatment consumption.
Time frame: Over 145 minutes after treatment consumption at each session, for a total of 2 weekly sessions.
GLP-1 will be measured in the plasma through intravenous blood collection at 0, 35, 65, 95, 125, and 145 minutes after treatment consumption.
Time frame: Over 145 minutes after treatment consumption at each session, for a total of 2 weekly sessions.
GLP-2 will be measured in the plasma through intravenous blood collection at 0, 35, 65, 95, 125, and 145 minutes after treatment consumption.
Time frame: Over 145 minutes after treatment consumption at each session, for a total of 2 weekly sessions.
GIP will be measured in the plasma through intravenous blood collection at 0, 35, 65, 95, 125, and 145 minutes after treatment consumption.
Time frame: Over 145 minutes after treatment consumption at each session, for a total of 2 weekly sessions.
Leptin will be measured in the plasma through intravenous blood collection at 0, 35, 65, 95, 125, and 145 minutes after treatment consumption.
Time frame: Over 145 minutes after treatment consumption at each session, for a total of 2 weekly sessions.
PYY will be measured in the plasma through intravenous blood collection at 0, 35, 65, 95, 125, and 145 minutes after treatment consumption.
Time frame: Over 145 minutes after treatment consumption at each session, for a total of 2 weekly sessions.
CCK will be measured in the plasma through intravenous blood collection at 0, 35, 65, 95, 125, and 145 minutes after treatment consumption.
Time frame: Over 145 minutes after treatment consumption at each session, for a total of 2 weekly sessions.
Ghrelin will be measured in the plasma through intravenous blood collection at 0, 35, 65, 95, 125, and 145 minutes after treatment consumption.
Time frame: Over 145 minutes after treatment consumption at each session, for a total of 2 weekly sessions.
Adiponectin will be measured in the plasma through intravenous blood collection at 0, 35, 65, 95, 125, and 145 minutes after treatment consumption.
Time frame: Over 145 minutes after treatment consumption at each session, for a total of 2 weekly sessions.
Amino acid concentrations will be measured in the plasma through intravenous blood collection at 0, 35, 65, 95, 125, and 145 minutes after treatment consumption.
Time frame: Over 145 minutes after treatment consumption at each session, for a total of 2 weekly sessions.
Appetite will be assessed through Adaptive Visual Analogue Scales (AVAS) questionnaires completed at 0, 20, 35, 50, 65, 95, 125 and 145 minutes after treatment consumption, and through an ad libitum pizza meal provided at 125 minutes post-treatment consumption, where participants will be instructed to eat until they are comfortably full over 20 minutes.
Contact information is provided by the study sponsor or research team.
Amira Amr, PhD
CONTACT
Corrina Zhou, MSc
CONTACT
University of Toronto
Other
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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