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NCT Number: NCT07545330

Effect of Circadian Timing of a Standardized Meal on Postprandial Glucose Response in Healthy Adults

This randomized crossover study aims to investigate the effect of circadian timing of a standardized meal (morning versus evening consumption) on postprandial glucose response in healthy adults. Postprandial glucose will be assessed using the incremental area under the curve (iAUC) over 120 minutes.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy adults aged 18 years and older
  • Able and willing to provide informed consent
  • Able to comply with study procedures

Exclusion criteria

  • Diagnosis of diabetes or any metabolic disorder affecting glucose regulation
  • Use of any medications
  • Pregnant or breastfeeding women
  • Night shift workers or individuals with irregular sleep patterns

Treatment and study plan

Standardized test meal

Other

The standardized test meal provided 50 g of carbohydrates of weighed portions of white bread and jam, served with 200 mL of water.

Primary outcomes

  1. Incremental Area Under the Curve (iAUC) for Postprandial Glucose

    Time frame: Baseline to 120 minutes after consumption of the standardized test meal

    The primary objective of this study is to investigate the effect of circadian timing of a standardized test meal (morning versus evening consumption) on postprandial glucose response in healthy adults, assessed as the incremental area under the curve (iAUC) for capillary blood glucose over 120 minutes following meal consumption

Secondary outcomes

  1. Peak Postprandial Glucose (Morning vs Evening)

    Time frame: Baseline to 120 minutes after consumption of the standardized test meal

    Peak capillary blood glucose concentration measured within 120 minutes after consumption of the standardized test meal, under morning and evening conditions

  2. Time to Peak Glucose (Morning vs Evening)

    Time frame: Baseline to 120 minutes after consumption of the standardized test meal

    Time required to reach peak capillary blood glucose concentration following meal consumption, under morning and evening conditions.

  3. Postprandial Glucose Profile (Morning vs Evening)

    Time frame: Baseline, 15, 30, 60, 90, and 120 minutes after consumption of the standardized test meal

    Capillary blood glucose concentrations measured at predefined time points following consumption of the standardized test meal, under morning and evening conditions.

Other outcomes

  1. Night Eating Behavior

    Time frame: Baseline

    Night eating behavior will be assessed using the validated Night Eating Questionnaire to characterize nocturnal eating patterns and support interpretation of variability in postprandial glucose responses.

  2. Sleep Duration and Quality

    Time frame: Baseline

    Sleep duration and quality will be assessed using a validated sleep questionnaire administered prior to each study visit to support interpretation of postprandial glucose responses.

  3. Chronotype

    Time frame: Baseline

    Chronotype will be assessed at baseline using the validated Questionnaire to characterize individual circadian preference and support interpretation of postprandial glucose responses.

Study contacts

Contact information is provided by the study sponsor or research team.

Wafa Alotaibi, PhD

CONTACT

[email protected]

+966500358622

Sponsors and collaborators

Lead sponsor

King Faisal University

Other

Collaborators

  • Saudi Food and Drug Authority

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 22, 2026
Registry last updated
Apr 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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