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Completed

NCT Number: NCT04236115

Comparison of Articaine and Prilocaine for Extraction of Maxillary Teeth

Ninety-five patients, aged between 16 and 70 years old, were included in this study. Patients were divided into two groups. Group one received Articaine 4% with 1:00.000 Adrenalines. Group two received Prilocaine with 3% Felypressin (0.03 I.U. per ml). Onset time of anaesthesia was objectively evaluated by using electronic pulp testing.

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Key information

Conditions

Overcoming the Failure of Anaesthesia Dental Extraction Maxillary Teeth

Age range

16 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Taibah University

Madinah, 41311, Saudi Arabia

About this study

85 patients in this study had successful local anaesthetic followed by extraction within the study duration time (10 minutes). However, there were six patients with failure anaesthesia (5 in prilocaine group and 1 in articaine group). By application Person's Chi-square test (x2), there were no significant differences in the number of the episodes of the anaesthetic success between articaine and prilocaine groups at time intervals (P-value = 0.5). T- test showed there have been no important variations within the mean onset time of anaesthesia for articaine and prilocaine buccal infiltrations (P-value =0.1).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients have one or two upper teeth for extraction, subject tooth or its adjacent must be vital, healthy patient or patient with mild systemic diseases (class I or II according to American Society of Anesthesiology).

Exclusion criteria

  • Patients excluded from this study if they have allergy to local anaesthetic agents or need surgical, or multiple teeth extraction.

Treatment and study plan

Articaine 4%

Drug

Articaine 4% is dental local anaesthetic agent

Prilocain 3%

Drug

prilocaine is dental local anaesthetic agent

adrenalin

Drug

adrenaline is a vasoconstrictor

Felypressin

Drug

Felypressin is a vasoconstrictor

Primary outcomes

  1. Does articaine, rather than prilocaine, increase the success rate of anaesthesia for extraction of maxillary teeth

    Time frame: 6 months

    to compare the anaesthetic performances of 3% prilocaine (the safest local anaesthetic) with 4 % articaine (the local anaesthetic with fastest onset time of action) when used for maxillary teeth extraction

Sponsors and collaborators

Lead sponsor

Taibah University

Other

Registry information

Official study title

Does Articaine, Rather Than Prilocaine, Increase the Success Rate of Anaesthesia for Extraction of Maxillary Teeth

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Jan 22, 2020
Registry last updated
Jan 22, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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