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NCT Number: NCT06992271

Comparing Two Eccentric Protocols on Muscle Damage

The purpose of this study will be to test whether a new way of weight training is more effective than typical weight training. The investigators expect that this new way will cause more exercise-induced muscle damage, which helps people build bigger muscles. Another purpose of this study will be to explore perceptions of how muscle soreness impacts participant activities of daily living.

Recruiting

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Key information

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

NYIT

Old Westbury, New York, 11568, United States

Location status: Recruiting

Location contact

Amerigo Rossi, EdD

CONTACT

[email protected]

516-686-3884

About this study

Participants will come to the lab for 3 sessions, plus two email follow-up questionnaires.

Session 1 (45 minutes)

  • Complete a demographic questionnaire
  • Self-assess muscle soreness
  • Walk on the treadmill to warm-up
  • Maximal voluntary contraction on the chest press
  • Two sets of eccentric (lowering) bench press at 75% of max

Session 2 (45 minutes)

  • Walk on the treadmill to warm up
  • Maximal voluntary contraction on the chest press
  • Three sets of 10 eccentric contractions at 75% of max
  • Repeat the maximal voluntary contraction on the chest press

Session 2 Follow-up Rate muscle soreness for each of the three days following Session 2 Answer open-ended questions about perceptions of the muscle soreness

Session 3 (45 minutes) Walk on the treadmill to warm up Maximal voluntary contraction on the chest press Three sets of 10 eccentric contractions at 75% of max Repeat the maximal voluntary contraction on the chest press

Session 3 Follow-up Rate muscle soreness for each of the three days following Session 2 Answer open-ended questions about perceptions of the muscle soreness

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Sixteen young adults (ages 18-35) will be enrolled in this study.
  • In order to be enrolled, they must have completed at least three months of resistance training in the past five years in order to minimize the learning effect and chance of injury.

Exclusion criteria

  • Since regular resistance training reduces the primary outcomes, muscle damage and soreness, individuals who currently participate in chest press resistance training at least once per week will be excluded.
  • Individuals who have musculoskeletal injuries in the shoulder, elbow or wrist that preclude pain-free resistance training, or who have underlying uncontrolled cardiovascular complications will also be excluded.
  • Women who are pregnant, or may consider becoming pregnant over the subsequent 2 months, will be excluded

Treatment and study plan

Fast Eccentric

Behavioral

Resistance training done quickly

Slow Eccentric

Behavioral

Resistance training done slowly

Primary outcomes

  1. Muscle soreness 1

    Time frame: 1 day

    Visual analog scale as indirect indicator of muscle damage. Scale of 1-5. Higher score = more soreness

  2. Muscle soreness 2

    Time frame: 2 days

    Visual analog scale as indirect indicator of muscle damage. Scale of 1-5. Higher score = more soreness

  3. Muscle soreness 3

    Time frame: 3 days

    Visual analog scale as indirect indicator of muscle damage. Scale of 1-5. Higher score = more soreness

  4. Maximal Voluntary Isometric Contraction Change

    Time frame: pre-intervention, immediately after the intervention

    Change in MVIC will be used to indicated muscle damage.

Study contacts

Contact information is provided by the study sponsor or research team.

Amerigo Rossi, Ed.D

CONTACT

[email protected]

516 686-3884

Sponsors and collaborators

Lead sponsor

New York Institute of Technology

Other

Registry information

Official study title

A Novel Eccentric Resistance Training Strategy to Maximize Exercise Induced Muscle Damage in Young Adults

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
May 28, 2025
Registry last updated
May 28, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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