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NCT Number: NCT07435181

Comparative Outcomes of Radiofrequency Ablation of Concealed and Manifest Accessory Pathways: a Single Center, Retrospective Observational Study

The aim of this observational, retrospective study is to evaluate, comparatively, procedural outcomes of APs (Accessory pathway) ablation according to the conduction properties (i.e., manifest vs. concealed) and to assess both short- and long-term outcomes of RFA (RF ablation).

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Key information

Conditions

Atrioventricular Reentrant Tachycardias Arrhythmias, Cardiac Cardiac Conduction System Disease Cardiovascular Abnormalities Cardiovascular Diseases Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Disease Heart Defects, Congenital Heart Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Pre-Excitation Syndromes Syndrome Tachycardia Tachycardia, Atrioventricular Nodal Reentry Tachycardia, Reciprocating Wolff-Parkinson-White (WPW) Syndrome Wolff-Parkinson-White Syndrome

Age range

5 year–60 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who consecutively underwent an electrophysiological (EP) study between 2005 and 2023 at San Raffaele Scientific Institute are included if they met one of the following criteria:

Patients referred for EP study due to:

  • EITHER clinical suspicion of paroxysmal supraventricular tachycardia without prior documentation of ventricular pre-excitation and/or supraventricular arrhythmia (SVA) on 12-lead surface electrocardiogram, OR with electrocardiographic evidence of SVA, AND electrophysiological confirmation of atrioventricular re-entrant tachycardia (AVRT) as the arrhythmic mechanism.
  • Ventricular pre-excitation documented on serial 12-lead surface ECGs, with or without clinical episodes suggestive of AVRT, who underwent catheter ablation of the accessory pathway based on:

The presence of high-risk electrophysiological features (e.g., short antegrade effective refractory period of the AP, rapid conduction during atrial fibrillation), or Induction of sustained AVRT during the EP study.

  • Aged between 5 to 60 years old

Exclusion criteria

  • Lack of pre-specified follow-up: only patients with at least 1 years follow-up ambulatory visit will be included in the study
  • REDO CA procedure

Treatment and study plan

Primary outcomes

  1. Acute procedural success

    Time frame: At the end of the index procedure

Secondary outcomes

  1. Procedural complexity

    Time frame: From the end of the index procedure to discharge and at the ambulatory follow-up visits

  2. Durability of successful radiofrequency ablation

    Time frame: From the end of the index procedure to discharge and at the ambulatory follow-up visits

Study contacts

Contact information is provided by the study sponsor or research team.

Marcello Cosenza, MD

CONTACT

[email protected]

02 2643 689

Simone Gulletta, MD

CONTACT

[email protected]

02 2643 7484

Sponsors and collaborators

Lead sponsor

IRCCS Ospedale San Raffaele

Other

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Feb 27, 2026
Registry last updated
Feb 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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