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Completed

NCT Number: NCT07140458

Comparative Effect of Box Breathing And Buteyko Breathing on Pulmonary Functions in Asthma

The aim of this study was to evaluate the Effectiveness of Box Breathing Technique and Buteyko breathing techniques in patients with Asthma, using both Clinical Pulmonary tests as well as Patient reported outcomes.

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Key information

Conditions

Asthma (Diagnosis) Asthma Breathing Exercises Bronchial Diseases Disease Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

25 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Islam center and Teaching Hospital

Sialkot, Punjab Province, 51310, Pakistan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subjects with bronchial asthma for more than one year
  • Subjects who are on regular treatment (both inhalers and medication).
  • Subjects who are conscious and cooperative.

Exclusion criteria

  • Subject with recent abdominal, thoracic surgery.
  • Subject with any Disability; Physical or Mental.
  • Subjects who have other chronic respiratory diseases, new or current smoker, and had respiratory tract infection.

Treatment and study plan

Buteyko breathing

Other

Buteyko Breathing is a technique focusing on controlled, reduced breathing to improve oxygen uptake and reduce hyperventilation-related symptoms using Air hunger.

Procedure:-

After gaining proper relaxation:

  • Exhale slowly, and then hold that breath.
  • Use the index finger and thumb to plug the nose.
  • Hold that breath until there is an urge to breathe, and then inhale.
  • Breathe normally for at least 10 seconds.
  • Repeat several times.

Box Breathing

Other

Box Breathing (4-4-4-4 Technique) - Box Breathing exercises boosts lung function by optimizing oxygen flow and activating relaxation responses.Each exercise Sessions included 20 cycles of Box Breathing.

The procedure of the box breathing cycle includes:

  • inhale for 4 seconds
  • Hold the breath for 4 seconds
  • Exhale for 4 seconds
  • Hold the breath for 4 seconds, and repeat.

Primary outcomes

  1. Lung Function tests (FVC)

    Time frame: through study completion, approximately 8 weeks

    Changes from Baseline, Lung function tests measure how well the lungs take in, hold, and move air, as well as how efficiently they transfer oxygen into the blood. These tests help diagnose and monitor respiratory diseases like asthma, COPD, pulmonary fibrosis, and restrictive lung diseases. Tets measures are compared against Normal value i.e: FVC ≥80%.

  2. Lung Function Test (FEV¹)

    Time frame: through study completion, approximately 8 weeks

    Changes from Baseline, Lung function tests measure how well the lungs take in, hold, and move air, as well as how efficiently they transfer oxygen into the blood. These tests help diagnose and monitor respiratory diseases like asthma, COPD, pulmonary fibrosis, and restrictive lung diseases. Test measures are compared against Normal value i.e: FEV¹ ≥80%.

  3. Lung Function test (FEV₁/FVC ratio)

    Time frame: through study completion, approximately 8 weeks

    Changes from Baseline, Lung function tests measure how well the lungs take in, hold, and move air, as well as how efficiently they transfer oxygen into the blood. These tests help diagnose and monitor respiratory diseases like asthma, COPD, pulmonary fibrosis, and restrictive lung diseases. Test measures are compared against Normal value i.e: FEV₁/FVC ≥0.7.

Secondary outcomes

  1. Modified Borg Dyspnea Scale

    Time frame: through study completion, approximately 8 weeks

    The Modified Borg Dyspnea Scale (MBS) is a subjective tool used to measure a patient's perceived breathlessness (dyspnea) during physical activity or at rest.

    Scoring System:

    -Scale Range: 0 to 10(with verbal descriptors for each level). Higher values signify worse condition (Maximal effort).

  2. Mcgill quality of life questionnaire

    Time frame: through study completion, approximately 8 weeks

    The MQOL is a validated tool designed to assess the quality of life (QoL) in patients with life-threatening or chronic illnesses. It focuses on *physical, psychological, existential, and social well-being*.

    Response Scale: Most items use a 0-10 numerical rating scale (higher = better QoL).

    • 0 = Worst possible experience
    • 10= Best possible experience Overall Higher scores indicate better quality of life. Whereas Lower scores suggest significant distress in a domain (e.g., pain, existential crisis).

Sponsors and collaborators

Lead sponsor

Riphah International University

Other

Registry information

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Aug 24, 2025
Registry last updated
Aug 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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