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OpenTrials
Completed

NCT Number: NCT01239277

Combined Nutrient Intake and Muscle Protein Synthesis

Dietary intervention to prevent sarcopenia in elderly people. The objective of this study is to test whether combined nutrient intake plays an important role in stimulation of the muscle protein growth in elderly people; and whether it represent effective strategies to overcome the impaired muscle protein synthesis in elderly when compared with young subjects.

Completed

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Key information

Conditions

Aging

Age range

70 year–85 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Universiteit Maastricht, Bewegingswetenschappen

Maastricht, Limburg, Netherlands

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • males
  • 70-85 years or 18-30 years
  • BMI < 30

Exclusion criteria

  • Type II diabetes
  • All co morbidities interacting with mobility and muscle metabolism of the lower limbs
  • Use of anticoagulants
  • Patients suffering from Phenylketonuria
  • Participation in any regular exercise programme

Treatment and study plan

Protein

Other

20g protein

protein and carbohydrate

Other

20g protein and 20g carbohydrate

protein and leucine

Other

20g protein, 2.5g leucine

Primary outcomes

  1. Muscle protein synthesis

    Time frame: 6 h postprandial period

    Muscle protein synthesis will be expressed as fractional synthetic rate (FSR) by dividing the increment in enrichment in the product, i.e. protein-bound C13phe, by the enrichment of the precursor (=plasma availability).

Sponsors and collaborators

Lead sponsor

Maastricht University Medical Center

Other

Registry information

Important dates

Study start
2011
Primary completion
2011
Study completion
2011
First posted
Nov 11, 2010
Registry last updated
Sep 14, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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