Combined Effects of INF and OEP in Patients With Diabetic Peripheral Neuropathy

This study addresses a gap in existing literature by comparing the effects of intraneural facilitation therapy and Otago exercise in improving balance, pain and QOL among DPN patients. While both Intraneural Facilitation (INF) therapy and the Otago Exercise Program have been acknowledged for their individual benefits, their comparative effectiveness in the context of diabetic peripheral neuropathy (DPN) has not been adequately explored. This study aims to bridge this gap by examining which intervention more effectively improves quality of life, reduces pain, and enhances balance in DPN patients, thus providing essential insights for optimizing treatment approaches.

Inclusion criteria

• Age 50-75years
• Both male and female patients will be included in the study
• Patient with type 2 diabetes mellitus (diagnosed by the physician)
• Patients with a score ≥ 4 on DN4 scale
• Patients have a score on the Timed Up-and-Go (TUG) test of less than 15 s
• Able to walk at least 10 meters long

Exclusion criteria

• Patient with presence of any other systemic disease rather than diabetes such as end-stage renal failure, uncontrolled hypertension, severe dyslipidemia, chronic liver disease, autoimmune disease, advanced chronic obstructive pulmonary disease etc
• Patients with documented active alcohol or drug misuse
• Patient with total or partial amputation of lower extremities
• Participants will be also excluded if they were morbidly obese or if pregnant (self-reported)
• Patient with active inflammations or other inflammatory neuropathies including chronic inflammatory demyelinating polyneuropathy, proximal diabetic neuropathy, chemotherapy-induced peripheral neuropathy, autonomic neuropathies, or other neuropathies not associated with DM such as B12 deficiency