Effects of Whole-body Vibration Therapy on Type 2 Diabetic Patients with and Without Polyneuropathy

Volunteers with type 2 diabetes mellitus with and without peripheric neuropathy will be evaluated in terms of any contra-indication that will restrain them from making exercise with whole body vibration device. 60 male or female volunteers who are suitable in terms of inclusion/exclusion criteria will be invited for the study. Volunteers will be randomly distributed to one of the 3 groups. Each group will contain 20 participants. 1st group will include type 2 diabetic patients with peripheric neuropathy and 2nd and 3rd groups will include type 2 diabetic patients without neuropathy. Patients in group 1 and 2 will make static isometric exercises on vibration platform whereas patients in group 3 will make the same exercises on land in the hospital setting. Participants will be requested to complete 3 months of exercise. They will be evaluated before and at the end of the 3 months of exercise with physical measures such as waist and hip circumference, 6-minute walk test, body composition measured by bioimpedance, muscle thickness, and blood tests to measure inflammatory biomarkers.

Inclusion criteria

• Participants must stand and walk o without using an assistive device.
• Participants must have a weight of less than 120 kg.

Exclusion criteria

• T2DM patients with advanced cardiovascular, renal, hepatic disease
• T2DM patients with diabetic retinopathy or nephropathy
• T2DM patients with untreated hypertension, rhythm disorders, and those who have undergone bypass surgery
• T2DM patients with ischemic changes in the resting ECG
• T2DM patients with untreated hypoglycemia or orthostatic hypotension
• T2DM patients who are unable to walk independently, or use of canes, crutches or wheelchairs
• T2DM patients who have open ulcers or wounds on load-bearing surfaces
• T2DM patients with inflammatory rheumatic diseases such as rheumatoid arthritis
• T2DM patients with active infectious disease
• T2DM patients with high risk of thrombosis, those with deep vein thrombosis
• T2DM patients who carry a pacemaker, prosthesis, intrauterine device or metal implant,
• T2DM patients with a history of cancer
• T2DM patients with severe migraine, epilepsy, stroke or other neurological disorders, those who have undergone brain surgery
• T2DM patients with non-diabetic neuropathy due to reasons such as HIV, AIDS, alcohol, uremia
• T2DM patients with cognitive impairment
• T2DM patients who are on psychotropic or neurotoxic therapy
• T2DM patients with advanced balance problems
• T2DM patients who are pregnant or breastfeeding mothers
• T2DM patients who are organ transplant recipients
• T2DM patients with hernia
• T2DM patients with kidney or bladder stones
• T2DM patients who are exposed to mechanical vibration due to their job