Combination Chemotherapy in Treating Patients With Recurrent or Refractory Leukemia or Lymphoma

OBJECTIVES:

• Determine non-hematologic toxic effects of high-dose cytarabine and high-dose mitoxantrone in patients with recurrent or refractory leukemia or lymphoma.
• Determine the in vitro T/NK lymphocyte proliferative responses to patient's leukemia/lymphoma cells before and after treatment with this regimen.

OUTLINE: Patients receive high-dose cytarabine IV over 1 hour on days 1-5 and high-dose mitoxantrone IV over 15-30 minutes on day 5. Patients also receive sargramostim (GM-CSF) subcutaneously beginning on day 14 and continuing until blood counts recover.

Patients who achieve at least stable disease or a response may receive a second course beginning at least 14 days after the first course is completed.

Patients are followed for 3 months.

PROJECTED ACCRUAL: A total of 20-30 patients will be accrued for this study within approximately 2-3 years.

DISEASE CHARACTERISTICS:

• One of the following must be present:

• Histologically confirmed acute myeloid leukemia or acute lymphoblastic leukemia

• More than 5% blasts in the bone marrow or peripheral blood unrelated to recovery of normal hematopoiesis from prior chemotherapy
• Failed at least 1 attempt at induction chemotherapy
• Diagnosis of non-Hodgkin's lymphoma or Hodgkin's lymphoma

• Refractory or relapsed after at least 1 regimen of standard chemotherapy
• Diagnosis of chronic myelogenous leukemia in accelerated phase or blast crisis

• Received at least 1 myelotoxic chemotherapy regimen
• Active CNS involvement allowed

PATIENT CHARACTERISTICS:

Age

• 55 and under

Performance status

• ECOG 0-2

Life expectancy

• At least 5 weeks

Hematopoietic

• Lymphoma patients:

• WBC at least 2,000/mm^3*
• Platelet count at least 20,000/mm^3* NOTE: *Unless due to bone marrow involvement or disease process

Hepatic

• Bilirubin no greater than 3 times normal*
• AST/ALT no greater than 3 times normal*
• Alkaline phosphatase no greater than 3 times normal*
• No severe liver failure NOTE: *Unless related to leukemia

Renal

• Creatinine clearance greater than 50 mL/min
• No severe renal failure

Cardiovascular

• LVEF at least 45% by MUGA

Pulmonary

• DLCO at least 60% of predicted

Other

• HIV negative
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• No psychiatric illness that would preclude informed consent
• No medical illness or other condition that would preclude study participation

PRIOR CONCURRENT THERAPY:

Biologic therapy

• Not specified

Chemotherapy

• See Disease Characteristics
• At least 24 hours since prior hydroxyurea
• At least 1 week since other prior chemotherapy

Endocrine therapy

• Not specified

Radiotherapy

• Not specified

Surgery

• Not specified

Other

• Recovered from prior therapy