Collagen Cross-linking in Infectious Keratitis Trial

The purpose of this study is to evaluate the efficacy of collagen cross-linking for treatment of infectious keratitis.

Completed

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Key information

Conditions

Infectious Keratitis Bacterial Keratitis Corneal Diseases Corneal Ulcer Eye Diseases Eye Infections Fungal Keratitis Infections Keratitis

Age range

6 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Ophthalmology department, King Chulalongkorn Memorial hospital

Pratumwan, Bangkok, 10330, Thailand

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Evidence of corneal ulcer grade II or III (bacteria or fungal, or presumed bacterial or fungal)
Age more than 6 year
Patients can understand and can follow the study protocol

Exclusion criteria

Pregnancy by history or urine test
Evidence of herpetic keratitis
Evidence of corneal perforation
Evidence of autoimmune disease
Known allergy to study medication

Treatment and study plan

Collagen cross-linking

Procedure

Collagen cross-linking arm will receive standard medication for corneal ulcer treatment and corneal collagen cross-linking.

Standard treatment arm will receive only standard medication.

Primary outcomes

decrement of infiltration size

Time frame: 1 months

decrement of infiltration size between day0 and day 30

Secondary outcomes

number of participants with adverse events

Time frame: 1 months

adverse events after corneal collagen cross-linking (report in descriptive study)

Sponsors and collaborators

Lead sponsor

Chulalongkorn University

Other

Registry information

Important dates

Study start: 2013
Primary completion: 2014
Study completion: 2014
First posted: Apr 15, 2013
Registry last updated: May 4, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed