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OpenTrials
Completed

NCT Number: NCT04383431

Cross-linking as Treatment in Infectious Keratitis

To compare between SCXL and ACXL for treatment of infectious keratitis

Completed

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Key information

Conditions

Infectious Keratitis

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of medicine

Sohag, 82425, Egypt

About this study

Standard epithelium-off CXL, 30 minutes soaking time with riboflavin, 30 minutes UVA corneal irradiation continuous mode (Group A). Accelerated CXL 11 minutes soaking time with riboflavin, 8 minutes UVA corneal irradiation pulsed mode (Group B).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Fungal infectious keratitis
  • bacterial infectious keratitis
  • Must be not responding to medication

Exclusion criteria

  • Viral keratitis
  • Pregnancy and lactation

Treatment and study plan

PACK-CXL

Procedure

Standard epithelium-off CXL, 12 minutes soaking time with riboflavin, 8 minutes UVA corneal irradiation pulsed mode.

Primary outcomes

  1. Corneal healing

    Time frame: 3 months

    Reepithelization of corneal ulcer which is measured in mm by slitlamp examination

  2. Corneal edema

    Time frame: 3 months

    measurement of corneal edema by measurement of the corneal thickness in um by Optical Coherent Tomography

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

Standard Cross-linking Versus Accelerated Photoactivated Chromophore Cross-linking (PACK-CXL) for Treatment of Infectious Keratitis: A Comparative Study

Important dates

Study start
2020
Primary completion
2023
Study completion
2023
First posted
May 12, 2020
Registry last updated
Jan 18, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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