Cohort Study of Inpatients and Outpatient Patients With Cerebral Small Vessel Disease

Research Objectives:

• To conduct a longitudinal study on patients with cerebral small vessel disease (CSVD) and observe the dynamic evolution of their cognitive functioning, emotional disorders, and other related factors.
• To explore and summarize the clinical and radiological characteristics of the CSVD population, and identify new risk factors for CSVD.
• To investigate in depth the underlying mechanisms and the relationship between clinical and radiological outcomes in CSVD.
• To establish a multifactor prediction model for cognitive and emotional disorders in CSVD.

Inclusion criteria

• Participants aged between 18 and 80 years, with no restriction on gender.
• Participants who have completed a 3.0T MRI of the head within one year at Yueyang Hospital, and meet the imaging diagnostic criteria of the 2013 STRIVE guidelines.
• Participants who have a Modified Rankin Scale (mRS) score of 0-2 (able to perform activities of daily living) at the time of the visit.
• Participants who are able to understand and agree to participate in the study, and have signed the informed consent form.

Exclusion criteria

• Diagnosis of symptomatic lacunar syndrome without 6 months of onset (participants can be enrolled after 6 months to avoid the impact of the acute phase).
• Intracranial and extracranial vascular examination confirms stenosis of the blood vessel by ≥50%.
• Imaging data reveals intracranial space-occupying lesions.
• A history of other neurological or mental illnesses with a definite diagnosis of the cause, including stroke (excluding lacunar infarctions), neurodegenerative diseases (such as Parkinson's disease and Alzheimer's disease).
• Co-occurring serious illnesses, such as malignant tumors, heart failure, respiratory failure, renal failure, severe liver dysfunction, severe blood system diseases, or gastrointestinal bleeding.
• Severe impairment in vision, hearing, language function, or limb muscular weakness that prevents completion of relevant tests.
• Women who are pregnant or breastfeeding.
• MRI scan contraindicated due to various reasons (such as claustrophobia).
• Any other reasons that prevent the collection of clinical data required for this study.