Registry Study of Cerebral Small Vessel Disease

Inclusion criteria

• Age above 50 years (including 50-year-old);
• MRI confirmed the presence of typical imaging changes of CSVD;
• Voluntary participation in the study and be willing to sign the Informed Consent Form.

Exclusion criteria

• Patients with acute ischemic stroke or acute intracranial hemorrhage (e.g., epidural hematoma, subdural hematoma, subarachnoid hemorrhage, intracerebral hemorrhage, etc.) or a history of cerebral infarction (non-lacunar) or intracranial hemorrhage within the past 3 months;
• Significant non-vascular white matter lesions (e.g., multiple sclerosis, adult-onset leukoencephalopathy, metabolic encephalopathy, etc.);
• Patients with a history of cognitive impairment due to other causes (e.g., normal pressure hydrocephalus, Alzheimer's disease, Parkinson's disease, multiple sclerosis, encephalitis, etc.);
• Severe hepatic, renal, or cardiac insufficiency (ALT or AST >2 times the upper limit of normal, or serum creatinine >1.5 times the upper limit of normal, or New York Heart Association [NYHA] functional class III or IV);
• Patients with psychiatric disorders that affect study medication administration and evaluation;
• Contraindications to MRI examination (e.g., claustrophobia, presence of an implantable pacemaker, etc.);
• Patients unable to comply with follow-up examinations or other study procedures due to residential location or other reasons;
• Participation in other clinical trial projects.