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NCT Number: NCT07743229

COG+OT Telerehabilitation for Adults With Subjective Cognitive Complaints

This pilot study will evaluate a comprehensive cognitive assessment approach and personalized neurocognitive telerehabilitation intervention for adults with subjective cognitive complaints (SCC). The study includes older adults with SCC and adults with Ehlers-Danlos Syndrome (EDS) and SCC. Participants will complete pre- and post-treatment assessments and receive a 6-week COG+OT telerehabilitation intervention that combines cognitive rehabilitation and occupational therapy strategies to support everyday functional cognition.

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Key information

Conditions

Subjective Cognitive Complaints Behavior Behavioral Symptoms Cardiovascular Diseases Cognition Disorders Cognitive Dysfunction Collagen Diseases Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Connective Tissue Diseases Ehlers-Danlos Syndrome Fatigue Genetic Diseases, Inborn Hematologic Diseases Hemic and Lymphatic Diseases Hemorrhagic Disorders Hemostatic Disorders Mental Disorders Mental Fatigue Neurocognitive Disorders Pathological Conditions, Signs and Symptoms Signs and Symptoms Skin Abnormalities Skin Diseases Skin Diseases, Genetic Skin and Connective Tissue Diseases Vascular Diseases

Age range

21 year and older

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Medical University of South Carolina, Charleston, South Carolina, United States

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Endorsement of subjective cognitive complaints as indicated by a score ≥4 on the Healthy Brain 9 (HB9)
  • Community-dwelling adult aged 60 years or older, or adult aged 21 years or older with a diagnosis of Ehlers-Danlos Syndrome (EDS)
  • English as the primary language
  • Access to and ability to use a smartphone compatible with the NeuroUX platform
  • Access to a device capable of supporting a telerehabilitation visit, such as a phone, tablet, or laptop, and a reliable Wi-Fi or cellular internet connection
  • Able to participate in study assessment sessions as determined by the licensed, experienced telerehabilitation occupational therapist

Exclusion criteria

  • Diagnosis of dementia or mild cognitive impairment
  • Significant or unstable conditions or treatments for medical conditions that may impact cognition, such as traumatic brain injury or brain tumor
  • Inability to engage in study-related procedures as determined by the study team

Treatment and study plan

COG+OT Telerehabilitation

Behavioral

COG+OT is a personalized telerehabilitation program that combines cognitive rehabilitation and occupational therapy. Cognitive rehabilitation sessions focus on strategies for attention, memory, organization, planning, problem solving, and executive function. Occupational therapy sessions use meaningful daily activities to support application and generalization of cognitive strategies in home- and community-based tasks. The intervention is delivered remotely over 6 weeks in 10 sessions lasting approximately 45 to 60 minutes each.

Primary outcomes

  1. Change in Everyday Cognition Scale-II (ECog-II) Score

    Time frame: Pre-treatment to post-treatment, approximately 8 weeks

    Change in subjective cognition measured using the Everyday Cognition Scale-II (ECog-II), a self-report measure assessing perceived cognitive functioning across everyday activities, including memory, executive function, language, and attention.

Secondary outcomes

  1. Retention Rate

    Time frame: Through study completion, approximately 8 weeks

    Feasibility measured as the percentage of participants who complete all study sessions.

  2. Adherence Rate

    Time frame: Through study completion, approximately 8 weeks

    Feasibility measured as the percentage of participants completing intervention activities for each session, including functional task practice and homework.

Study contacts

Contact information is provided by the study sponsor or research team.

Michelle Woodbury, PhD, OTR/L

CONTACT

[email protected]

Patricia Finetto, OTR/L

CONTACT

[email protected]

843-792-8533

Sponsors and collaborators

Lead sponsor

Medical University of South Carolina

Other

Registry information

Official study title

A Comprehensive Cognitive Assessment Protocol and Innovative Neurocognitive Telerehabilitation Pilot Program for Adults With Subjective Cognitive Complaints

Acronym: CogSCC

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Aug 3, 2026
Registry last updated
Aug 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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