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OpenTrials
Completed

NCT Number: NCT00245232

Cognitive Processing Therapy Versus Its Individual Components in the Treatment of Post-Traumatic Stress Disorder and Depression in Women Who Have Been Sexually Abused

This study will evaluate the effectiveness of cognitive processing therapy versus its individual components in treating women with post-traumatic stress disorder (PTSD) and depression brought on by sexual assault.

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Key information

Age range

18 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Center for Trauma and Recovery, University of Missouri - St. Louis

St Louis, Missouri, 63121-4499, United States

About this study

PTSD is a psychiatric disorder that can occur following exposure to a traumatic event in which grave physical harm occurred or was threatened. PTSD is marked by clear biological changes as well as psychological symptoms. Many people with PTSD repeatedly relive the trauma in the form of flashback episodes, memories, nightmares, or frightening thoughts. This study will evaluate the effectiveness of cognitive processing therapy versus its individual components in treating women with post-traumatic stress disorder and depression brought on by sexual assault.

Participants in this single-blind study will be randomly assigned to receive one of three treatments: cognitive processing therapy (CPT); cognitive therapy (CT); or written exposure (WE). Participants assigned to receive either CPT or CT will attend therapy sessions twice weekly for 6 weeks. CPT will focus on helping each individual to process accurate memories of the traumatic event and to work through any memories that cannot be completely ignored, nor completely integrated back into their thinking. Also included in CPT will be a WE component, in which participants will be encouraged to recall the traumatic event and experience any emotions connected to it. CT will be similar to CPT, but will not include the WE component. Participants assigned to receive only WE will attend one 2-hour session each week. Symptoms of PTSD and depression will be measured at baseline, post-treatment, and at a 6-month follow-up visit.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • History of a discrete episode of assault in childhood or adulthood
  • Meets criteria for post-traumatic stress disorder

Exclusion criteria

  • Experienced a traumatic event that was in the form of chronic ongoing abuse and not a discrete incidence
  • Psychosis
  • Mental retardation
  • Suicidal or parasuicidal
  • Currently addicted to drugs
  • Illiterate
  • Currently in an abusive relationship
  • Currently being stalked

Treatment and study plan

cognitive therapy

Behavioral

cognitive processing therapy

Behavioral

Written Exposure

Behavioral

Primary outcomes

  1. Depression symptoms; measured immediately post-treatment and 6 months post-treatment

  2. Post-traumatic stress disorder symptoms; measured immediately post-treatment and 6 months post-treatment

Sponsors and collaborators

Lead sponsor

University of Missouri, St. Louis

Other

Collaborators

  • National Institute of Mental Health (NIMH)

Registry information

Official study title

Cognitive Processes in PTSD: Treatment

Important dates

Study start
2000
Study completion
2005
First posted
Oct 27, 2005
Registry last updated
Mar 31, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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