Skip to main content
OpenTrials
Completed

NCT Number: NCT03519789

Cognitive and Emotional Factors in Visual Exploration Among Patients With Post-Traumatic Stress Disorder (SAILLANCE2)

Post-traumatic stress disorder (PTSD) is characterized by hypervigilance. In particular, previous works suggest that patients tend to scan constantly the environment for possible threats. The present project aims at investigating such attentional bias in patients with PTSD using the change blindness paradigm that offers the interesting possibility of studying sensitivity to sudden changes using ecological stimuli. More precisely, the investigators will investigate whether patients are more sensitive than matched controls to sudden changes in the visual environment and whether this hypersensitivity is specific or even stronger when visual information has an emotional content. The attentional bias will be measured using motor responses (accuracy and speed to indicate the occurrence of a change by pressing a button) as well as eye movements.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Post-traumatic Stress Disorder Mental Disorders Stress Disorders, Post-Traumatic Stress Disorders, Traumatic Trauma and Stressor Related Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital, Lille

Lille, 59037, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • a diagnosis of PTSD based on the standard DSM-IV criteria,
  • normal or corrected vision.
  • clinically stable at the testing time

Exclusion criteria

  • history of neurological illness or trauma that occurred in the previous six months, - pregnant and nursing women,
  • drugs use in the last 24 hours,
  • an acute ocular disorder.
  • Participants will not be under tutorship, curatorship or deprived of liberty.

Treatment and study plan

Primary outcomes

  1. Response time before the detection of neutral and emotional stimuli.

    Time frame: Baseline: one session

    The explicit response of the participants will be measured with the response time before the detection of neutral and emotional stimuli.

Secondary outcomes

  1. Number of correct detections compared with the missed detections and false alarms.

    Time frame: Baseline: one session

    Performances will be measured by a sensitivity index (D prime) . This sensitivity index considers the number of correct detections compared with the missed detections and false alarms.

  2. Total duration until the participant first fixed on a ROI.

    Time frame: Baseline: one session

    The implicit response will be measured by the localization and duration of fixations. All fixations outside the recording field will be excluded. The main variable will be the mean latency of the first fixation in a region of interest (ROI). This variable corresponds to the total duration until the participant first fixed on a ROI.

Sponsors and collaborators

Lead sponsor

University Hospital, Lille

Other

Registry information

Official study title

Cognitive and Emotional Factors in Visual Exploration Among Patients With Post-Traumatic Stress Disorder

Acronym: SAILLANCE2

Important dates

Study start
2014
Primary completion
2020
Study completion
2020
First posted
May 9, 2018
Registry last updated
May 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.