Cognitive Correlates of Antidepressant Treatment Response in Elders

Major depression is a very common health problem affecting older persons. The present standard of treatment is with medications called "antidepressants". Antidepressants have been studied extensively in older persons with normal brain function and have been shown to be effective. However, certain types of brain dysfunction called "executive impairment" (inability to do higher order thinking) may lead to poor treatment outcomes. This study will compare how older depressed people with different levels of executive impairment respond differently to standard antidepressant treatment. Knowing this information will lead to more rational targeting of available treatments, leading to improved treatment outcomes.

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Key information

Conditions

Depression Behavior Behavioral Symptoms

Age range

65 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

St Michael's Hospital

Toronto, Ontario, M5B 1W8, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

above the age of 65,
speak English fluently,
experience depression, AND
not yet on active treatment.

Exclusion criteria

active delirium,
substance abuse,
mental illness other than major depression,
active CNS disease,
unstable systematic medical disease, OR
current of past psychotic disorder.

Treatment and study plan

Zoloft (antidepressant)

Drug

Zoloft 50-200 mg po od x 12 weeks

Other names: Sertraline

Primary outcomes

depression

Time frame: June 1, 2007 - June 1, 2008

Sponsors and collaborators

Lead sponsor

Unity Health Toronto

Other

Registry information

Official study title

Determining the Impact of Dementia and Executive Impairment on Antidepressant Treatment Response in Older Persons

Important dates

Study start: 2007
Primary completion: 2009
Study completion: 2009
First posted: Nov 22, 2011
Registry last updated: Nov 22, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed