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OpenTrials
Completed

NCT Number: NCT01947179

Cognitive Anxiety Sensitivity Treatment for Suicide

The purpose of this study is to test the effectiveness and usability of a computer-based treatment for mood and anxiety relevant risk factors. The target of the treatment is related to cognitive stress, which has been shown to be associated with several negative mental health outcomes such as suicidal ideation, substance use disorders, and Post-Traumatic Stress Disorder.

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Key information

Conditions

Anxiety Anxiety Disorders Mental Disorders

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Florida State University

Tallahassee, Florida, 32304, United States

About this study

CAST is a newly developed computerized treatment targeting specific risk factors associated with PTSD, substance use, anxiety, and suicide. Eligible individuals will be randomized to one of two conditions. In both conditions, participants will complete various self-report questionnaires and a computerized presentation. Additionally, all participants will be asked to complete a one month follow-up appointment.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • At or above the community sample mean on the ASI
  • English speakers
  • 18 years of age or older

Exclusion criteria

  • Significant medical illness
  • Current substance dependence
  • Current or past psychotic-spectrum disorders
  • Uncontrolled bipolar disorder
  • Serious suicidal intent that warranted immediate medical treatment

Treatment and study plan

Anxiety Risk Reduction

Behavioral

Involves psychoeducation and interoceptive exposure exercises

Primary outcomes

  1. Anxiety Sensitivity Index (ASI)

    Time frame: Month one follow-up

    The ASI is a 16-item self-report measure of anxiety sensitivity. Each item consists of a possible negative consequence of anxiety symptoms. The scale assesses three AS subfactors including cognitive, physical, and social concerns. The measure has shown good psychometric properties.

Secondary outcomes

  1. Beck Suicide Scale (BSS)

    Time frame: Month one follow-up

    The BSS is a 21-item widely used self-report measure assessing a broad spectrum of behaviors and attitudes related to suicide risk, including suicidal ideation and past suicide attempts. It has demonstrated strong reliability and validity.

Other outcomes

  1. Posttraumatic Diagnostic Scale (PDS)

    Time frame: Month one follow-up

    The PDS is a self-report measure used to assess the severity of posttraumatic stress symptoms during the past month. The measure was designed based on Diagnostic and Statistical Manual-IV criteria. Respondents report if they have experienced any of 12 traumatic events, including an "other" category, and then indicate which event was the most disturbing. Additionally, respondents rate the frequency of 17 PTSD symptoms experienced in the past month in relation to the most disturbing event they endorsed. The PDS has excellent psychometric properties and can be used as a continuous measure of PTSD symptom severity.

Sponsors and collaborators

Lead sponsor

Florida State University

Other

Collaborators

  • United States Department of Defense

Registry information

Official study title

Development and Evaluation of a Brief, Suicide Prevention Intervention Reducing Anxiety Sensitivity

Acronym: CAST

Important dates

Study start
2011
Primary completion
2013
Study completion
2013
First posted
Sep 20, 2013
Registry last updated
Sep 26, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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