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Completed

NCT Number: NCT02540005

Coagulation Disorders After Aneurysmatic Subarachnoid Haemorrhage

The main purpose of this study is to analyse the on-going coagulation process after aSAH. For investigation the investigators use the rotational thromboelastometry (ROTEM) which is a point-of-care test using a variety of activators to provide a targeted and a dynamic analysis of coagulation cascade. This is a prospective, observational clinical study done in 16 aSAH patients treated in Tampere University Hospital intensive care unit and 16 control patients (elective craniotomy due to non-ruptured intracranial aneurysm.

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Key information

Conditions

Aneurysmatic Subarachnoid Haemorrhage

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Tampere University Hospital

Tampere, Pirkanmaa, 33521, Finland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years
  • Acute subarachnoid haemorrhage (confirmed by computed tomography, CT, or cerebrospinal fluid erythrocyte count over 1000 x 106/l) AND confirmed origin either with computed angiography (CTA) or digital subtraction angiography (DSA)
  • Onset of symptoms ≤ 12 hours
  • Expected to stay 72 hours in the ICU

Exclusion criteria

  • Pregnancy
  • Any long-term anticoagulant medication, except for low-dose aspirin (<150 mg/day)
  • Known active cancer

Treatment and study plan

ROTEM analysis

Other

Primary outcomes

  1. ROTEM analysis: MCF (mm) by EXTEM activators

    Time frame: 12 hours

Sponsors and collaborators

Lead sponsor

Tampere University Hospital

Other

Collaborators

  • CSL Behring

Registry information

Important dates

Study start
2015
Primary completion
2016
First posted
Sep 3, 2015
Registry last updated
Jun 28, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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