Coagulation and Fibrinolysis as Virulence Factors for Invasive Staphylococcus Aureus and Streptococcus Infections

the aim of this study is to investigate the role of staphylokinase, streptokinase and MMP activation in invasive staphylococcal and streptococcal infections.

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Key information

Conditions

Infective Endocarditis Cardiovascular Diseases Endocarditis Fasciitis Fasciitis, Necrotizing Heart Diseases Musculoskeletal Diseases Necrotizing Fasciitis

Sex eligibility

All sexes

Study type

Observational

Primary location

UZ Leuven University Hospital

Leuven, 3000, Belgium

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

all patients that undergo surgical treatment for invasive streptococcal or staphylococcal infections, including acute infective endocarditis and necrotizing fasciitis, from the UZ Leuven University Hospital

Exclusion criteria

none

Treatment and study plan

Primary outcomes

proteolytic activity

Time frame: 1 day (on date of surgery (tissue sample))

Sponsors and collaborators

Lead sponsor

Universitaire Ziekenhuizen KU Leuven

Other

Registry information

Official study title

Coagulation and Fibrinolysis as Virulence Factors for Invasive Staphylococcus Aureus and Streptococcus Infections.

Important dates

Study start: 2012
Primary completion: 2020
Study completion: 2020
First posted: Nov 21, 2012
Registry last updated: Sep 5, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed