Skip to main content
OpenTrials
Completed

NCT Number: NCT04284644

Co-induction Technique Compared to Standard Inhalational and Intravenous Induction Techniques

Co-induction technique refers to the use of a combination of medications to reach the desired therapeutic target. In the present study, the investigators examined the safety of a novel co-induction approach that relied on a simple timing and dosing alterations to the classical approaches of inhalational sevoflurane and propofol induction. The significance of this study is to find a reliable safe alternative method of induction that can provide optimal parameters,when compared to the classical methods of induction.

Completed

Looking for future studies?

Notify Me

Key information

Age range

65 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Jordan University Hospital

Amman, 11942, Jordan

About this study

Co-induction technique refers to the use of a combination of medications to reach the desired therapeutic target. This technique is considered an approach that can be of a great benefit to patients with chronic medical illnesses and those who have moderate to high risk for general anaesthesia.

In the present study, the investigators examined the safety of a novel co-induction approach that relied on a simple timing and dosing alterations to the classical approaches of inhalational sevoflurane and propofol induction. The significance of this study is to find a reliable safe alternative method of induction that can provide optimal parameters,when compared to the classical methods of induction. The investigators evaluated the time needed for laryngeal mask airway (LMA) insertion, number of LMA insertion trials, succession of LMA insertion, adverse events related to the airway, respiratory and cardiovascular systems, haemodynamic stability and satisfaction scores of enrolled patients.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with Age ≥ 65 years.
  • American Society of Anaesthesiologists' (ASA) score II or III.
  • minimally invasive endoscopic urological procedures.

Exclusion criteria

  • patient refusal.
  • Age < 65 years.
  • family history of malignant hyperthermia.
  • prolonged surgery that needed intubation.
  • body mass index (BMI) > 35 kg/m2.

Treatment and study plan

Induction using propofol

Drug

Patients were given 1.5 mcg/Kg of fentanyl intravenously. two minutes after the fentanyl dose, a dose of 1.5 mg/kg of propofol slowly over 2 minutes.

Induction using sevoflurane

Drug

Patients were given 1.5 mcg/Kg of fentanyl intravenously. two minutes after the fentanyl dose, patient received 8% inhalational sevoflurane through sealed plastic face mask at 8 L/min flow of oxygen.

Induction using propofol and sevoflurane

Drug

Patients were given 1.5 mcg/Kg of fentanyl intravenously. two minutes after the fentanyl dose, patient received 4% sevoflurane through sealed plastic face mask at 8 L/min flow of oxygen for 2 minutes, followed by a dose of 0.75 mg/kg of propofol given slowly.

Primary outcomes

  1. Intraoperative respiratory adverse events

    Time frame: 8 months

    The investigators recorded the occurrence of transient apnea intraoperatively, in addition to laryngeal spasm, coughing, gagging and increased salivation. The study chart included the documentation these common adverse events, the timing of occurrence, and the intervention required to manage these events.

Secondary outcomes

  1. Time for successful laryngeal mask airway insertion

    Time frame: 8 months

    The investigators assessed the time needed for LMA insertion. The timer was started upon giving the fentanyl, recording the time till successful insertion of laryngeal mask airway.

  2. Blood pressure stability

    Time frame: 8 months

    The investigators recorded patients' blood pressure readings throughout the induction procedure.

  3. Heart rate stability

    Time frame: 8 months

    The investigators recorded patients' heart rate throughout the induction procedure.

  4. Changes in oxygen saturation

    Time frame: 8 months

    The investigators recorded patients' oxygen saturation throughout the induction procedure.

Sponsors and collaborators

Lead sponsor

University of Jordan

Other

Registry information

Official study title

A Novel Co-induction Technique Compared to Standard Inhalational and Intravenous Induction Techniques: a Prospective Randomized Control Study

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Feb 26, 2020
Registry last updated
Feb 26, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.