Clinical Trial of Continuing Treatment for Patients Who Have Participated on a Prior Protocol Investigating Tanespimycin

Inclusion criteria

• Age >= 18 years
• Participated in and completed a previous Tanespimycin protocol without evidence of unacceptable toxicity and is deemed by the Investigator to be deriving benefit from the Tanespimycin drug as defined in the previous protocol
• All patients must rollover to this continuation protocol within 30 days of the last dose of Tanespimycin in the previous protocol, unless previously approved by the Medical Monitor
• All Adverse Events from the prior protocol, must have resolved to NCI CTCAE (v. 3.0) Grade <= 2
• The following laboratory results, within 10 days of Tanespimycin administration:
• Hemoglobin >= 8 g/dL
• Absolute neutrophils count >= 1.0x 10*9* /L
• Platelet count >= 50 x 10*9* /L
• Serum bilirubin <= 2 x ULN
• AST <= 2.5 ULN
• Serum creatinine <= 2 x ULN
• ECOG performance status of 0, 1 or 2
• Signed informed consent

Exclusion criteria

• Pre-existing neuropathy of CTCAE Grade >= 3 due to any cause
• Documented hypersensitivity reaction of CTCAE Grade >= 3 to prior therapy containing Cremophor (for those patients receiving Tanespimycin Injection)
• Pregnant or breast-feeding women
• Administration of chemotherapy, biological, immunotherapy or investigational agent (therapeutic or diagnostic), excluding Tanespimycin within 21 days prior to receipt of study medication
• Any medical conditions that, in the Investigator's opinion, would impose excessive risk to the patient