Clinical Trial of CBASP for Individuals… | Clinical Trial

Key information

Conditions

Depressive Disorder Alcohol-Related Disorders Alcoholism Chemically-Induced Disorders Depressive Disorder, Major Dysthymic Disorder Major Depressive Disorder Mental Disorders Mood Disorders Substance-Related Disorders

Age range

21 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Virginia Center for Addiction Research & Education (UVa CARE)

Charlottesville, Virginia, 22911, United States

About this study

This study examines the effectiveness of Cognitive Behavioral Analysis System of Psychotherapy (CBASP) in reducing both alcohol consumption and depressive symptoms in adults who are chronically depressed and alcohol dependent. Participants will receive a 20-session course of CBASP psychotherapy over a period of 21 weeks and will be assessed for severity of pretreatment psychological abuse and trauma as well as pre and posttreatment interpersonal functioning. Two primary hypotheses are to be tested: 1) demonstrate that CBASP is effective in reducing depressive symptoms (Hamilton Rating Scale for Depression-24 ratings) and alcohol consumption (drinks per drinking day) in this chronically depressed alcohol dependent cohort when posttreatment ratings are compared to pretreatment levels; and 2) demonstrate that acquisition of feeling safe with the therapist and acquisition of the ability to perceive the interpersonal consequences of one's behavior will significantly increase from pre to posttreatment levels and will be associated with reductions in drinking and depressive symptoms.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Clinical diagnosis of a current major depressive disorder (e.g., Major Depression, Dysthymic Disorder) for a minimum of two years
Clinical diagnosis of alcohol dependence during the last thirty days
Interest in changing one's drinking and alleviating depressive symptoms

Exclusion criteria

Please call study site for additional information

Treatment and study plan

Cognitive Behavioral Analysis System of Psychotherapy

Behavioral

Cognitive Behavioral Analysis System of Psychotherapy (CBASP) is a behavioral intervention that addresses the unique behavioral characteristics of chronically depressed individuals, most of which are highly relevant for alcoholics as well. CBASP has a structured, individualized, and collaborative (patient and clinician) design. The intervention emphasizes teaching effective coping strategies and employing motivational, cognitive, behavioral, and interpersonal techniques. Individual therapy (1 hour) sessions occur on a weekly basis for a total of 20 sessions over a period of 21 weeks.

Other names: CBASP

Primary outcomes

Depression Rating

Time frame: Baseline and 20 weeks

Change in depression rating scale over time.
Drinking behavior

Time frame: Baseline and 20 weeks

Change in number of drinks consumed per day over time.

Sponsors and collaborators

Lead sponsor

University of Virginia

Other

Registry information

Important dates

Study start: 2011
Primary completion: 2015
Study completion: 2018
First posted: Feb 8, 2012
Registry last updated: Apr 17, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed