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Completed

NCT Number: NCT07067541

Clinical Observation of Topical Lidocaine Cream Combined With Moisturizing Cream in the Treatment of Atopic Dermatitis

Twenty-five patients with atopic dermatitis applied lidocaine cream plus a moisturizer to the right limb and lidocaine cream alone to the left limb, twice daily for four weeks.

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Key information

Conditions

Atopic Dermatitis Congenital, Hereditary, and Neonatal Diseases and Abnormalities Dermatitis Dermatitis, Atopic Genetic Diseases, Inborn Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Skin Diseases Skin Diseases, Eczematous Skin Diseases, Genetic Skin and Connective Tissue Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

First Affiliated Hospital of Kunming Medical University

Kunming, Yunnan, 650000, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or female patients aged 18-65 years.
  • Clinical diagnosis of atopic dermatitis according to the 2020 Guidelines for the Diagnosis and Treatment of Atopic Dermatitis in China (symmetrical eczematous lesions for ≥6 months plus personal/family atopy history or elevated IgE/eosinophilia).
  • Voluntarily signed informed consent form.

Exclusion criteria

  • Active heart, liver, kidney, or other serious systemic illness.
  • History of viral or bacterial infection within 1 month prior to enrollment.
  • Immunocompromised patients or those receiving systemic immunosuppressive therapy.
  • Known allergy to lidocaine, moisturizer components, or any study-related topical agents.
  • Pregnant or breastfeeding women.
  • Use of topical corticosteroids or calcineurin inhibitors within 2 weeks prior to enrollment.

Treatment and study plan

Control lidocaine cream

Drug

lidocaine cream alone

Experimental lidocaine cream + moisturizer cream

Drug

lidocaine cream + moisturizer cream

Primary outcomes

  1. change in SCORAD (SCORing Atopic Dermatitis) from baseline

    Time frame: 4 weeks

    For each patient, a score will be obtained at baseline, after 4 weeks. The minimum score is 0 (best outcome) and the maximum score is 103 (worst outcome).

Sponsors and collaborators

Lead sponsor

First Affiliated Hospital of Kunming Medical University

Other

Registry information

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Jul 16, 2025
Registry last updated
Jul 16, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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