Clinical Efficacy of Biomimetic Hydroxyapatite in the Treatment of Molar Incisor Hypomineralization.

Primary outcomes

1. Change of BI - Bleeding Index

   Time frame: Study begin, 1,2,3, 6 and 9 months

   Scoring criteria:

   • 0: absence of bleeding after 30 seconds
   • 1: bleeding observed after 30 seconds
   • 2: immediate bleeding

2. Change of GI - Gingival Index (Loe and Silness, 1963)

   Time frame: Study begin, 1,2,3, 6 and 9 months

   Scoring criteria:

   • 0 = normal gingiva.
   • 1 = mild inflammation, edema and swelling; no bleeding.
   • 2 = moderate inflammation with edema, swelling and bleeding on probing.
   • 3 = severe inflammation with marked edema, redness tissues, ulceration and spontaneous bleeding.

3. Change of PCR - Plaque Control Record (O'Leary, 1972)

   Time frame: Study begin, 1,2,3, 6 and 9 months

   4 surfaces scored (mesial, distal, vestibular, labial/palatal) per tooth by means of plaque relevator.

   The Index is calculated multiplying the total number of surfaces with plaque per 100.

4. Change in Schiff Air Index - Dental sensitivity test

   Time frame: Study begin, 1,2,3, 6 and 9 months

   Scoring criteria:

   • the subject did not respond to air blasting;

   • the subject responded to air blasting;
   • the subject responded to air blasting and requested discontinuation;
   • the subject responded to air blasting, requested discontinuation and considered the stimulus to be painful.

5. Change of BEWE Index - Basic Erosive Wear Examination (Barlet et al., 2008)

   Time frame: Study begin, 1,2,3, 6 and 9 months

   Scoring criteria:

   • 0: no erosive tooth wear;
   • 1: initial loss of surface texture;
   • 2: distinct defect, hard tissue loss < 50% of the surface area;
   • 3: hard tissue loss ≥ 50% of the surface area.

   Additionally, risk level for clinical management will be assessed.