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NCT Number: NCT05999188

Clinical Characteristics and Prognosis of Aortic Dissection in China (CLASSIC)

This study will construct a retrospective-prospective long-term follow-up cohort and management system for aortic dissection through a multicentre collaborative network. This study aims to investigate the disease characteristics, progression patterns, clinical features, natural course and factors affecting the disease course and prognosis of patients with aortic dissection by retrospectively collecting data and prospectively enrolling patients.

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Key information

Conditions

Aortic Dissection Acute Aortic Syndrome Aneurysm Aortic Diseases Cardiovascular Diseases Dissection, Blood Vessel Vascular Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

First Affiliated Hospital of Xian Jiantong University

Xi'an, Shaanxi, 710061, China

Location status: Recruiting

Location contact

Guoliang Li

CONTACT

[email protected]

About this study

This study aims to construct a retrospective-prospective long-term follow-up cohort and management system for aortic dissection through a multicentre collaborative network. The duration of the study will be divided into retrospective and prospective components. The retrospective study will collect cases of aortic dissection of different aetiologies from 2003-2022; the prospective study is expected to collect cases of aortic dissection from 2022-2030. The study is expected to assess the disease characteristics, progression patterns, clinical features, natural course and long-term prognosis of aortic coarctation.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-80 years;
  • Meet diagnostic criteria for aortic dissection.

Exclusion criteria

  • Age <18 years or >80 years;
  • Women who are pregnant and breastfeeding;
  • Patients and their families refuse or are unable to sign the informed consent form.

Treatment and study plan

Observational

Other

No interventions will be given to patients.

Primary outcomes

  1. Change of post-operative survival rate

    Time frame: 3, 6, 9 month and 1, 2, 3, 4, 5 year after the surgery.

    Post-operative survival rate of patients after aortic dissection surgery in 3, 6, 9 month and 1, 2, 3, 4, 5 year. The survival situation will be assessed by telephone follow-up.

Secondary outcomes

  1. Change of the incidence of MACCE

    Time frame: 3, 6, 9 month and 1, 2, 3, 4, 5 year after the surgery.

    Major adverse cardio-cerebrovascular events included myocardial infarction, stroke, revascularization and all-cause death. The occurrence of MACCE will be assessed by telephone follow-up and medical records.

  2. Incidence of any complications

    Time frame: 5 years after the surgery.

    Any complications diagnosed by doctors. The occurrence of complications will be decided by medical records.

Study contacts

Contact information is provided by the study sponsor or research team.

Guoliang Li

CONTACT

[email protected]

0086-029-13759982523

Yang Yan

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

First Affiliated Hospital Xi'an Jiaotong University

Other

Collaborators

  • 521 Hospital of NORINCO Group
  • Henan Provincial People's Hospital
  • Shaanxi Provincial People's Hospital
  • Xiangyang Central Hospital

Registry information

Official study title

Clinical Characteristics and Prognosis of Aortic Dissection in China (CLASSIC): a National, Multicenter, Retrospective-prospective, Cohort Study

Acronym: CLASSIC

Important dates

Study start
2023
Primary completion
2030
Study completion
2030
First posted
Aug 21, 2023
Registry last updated
Jul 12, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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