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NCT Number: NCT06435195

Clinical Characteristics and Analysis of Pituitary Complex and Rare Diseases

The goal of this observational study is to systematically describe the clinical characteristics and outcomes of patients with pituitary complex and rare diseases at Peking Union Medical College Hospital. The main questions it aims to answer are:

* What are the influencing factors and rates of remission? * What are the comorbidities associated with these diseases? * What are the perioperative events, radiological findings, and pathological features?

Researchers will compare different patient groups to see if there are significant differences in these outcomes.

Participants will:

* Undergo detailed clinical evaluations. * Provide medical history and data for analysis. * Participate in follow-up assessments to monitor disease progression and treatment outcomes.

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Key information

Conditions

Pituitary Diseases Brain Diseases Central Nervous System Diseases Endocrine System Diseases Hypothalamic Diseases Nervous System Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Peking Union Medical College Hospital

Beijing, Beijing Municipality, 100730, China

Location status: Recruiting

Location contact

Yong Yao, MD

CONTACT

[email protected]

+8669152530

About this study

The study aims to provide a comprehensive analysis of pituitary complex and rare diseases at Peking Union Medical College Hospital. By leveraging a large cohort, the research will explore various clinical characteristics and outcomes. Specifically, the study will examine influencing factors and rates of remission, the presence of comorbidities, and perioperative events. Additionally, it will evaluate radiological findings and pathological features to better understand these conditions. Through this detailed investigation, the study seeks to enhance knowledge and inform clinical practice regarding the management and prognosis of pituitary complex and rare diseases.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed with rare sellar diseases including but not limited to pituitary adenomas (such as Thyrotropin-secreting pituitary adenomas, GH-secreting adenomas), craniopharyngiomas, Rathke's cleft cysts, sellar region germ cell tumors, cavernous sinus syndrome, and other diseases
  • Detailed medical history, including clinical symptoms, treatment plans and follow-up outcomes

Exclusion criteria

  • Incomplete medical records, especially missing key imaging diagnostic results
  • Patients with coexisting primary central nervous system diseases unrelated to sellar region diseases (such as severe traumatic brain injury)
  • Patients whose sellar region pathological diagnosis was changed or overturned during the follow-up period

Treatment and study plan

Surgical Removal

Procedure

Resection of pituitary pathologies.

Biopsy

Procedure

Taking a small tissue or liquid sample from the pituitary pathologies and the affected area for examination and diagnosis

Primary outcomes

  1. Remission

    Time frame: Postoperative one week and extends to the latest follow-up, estimated at up to 3 years

    Hormonal normalization and free of pathologies

Secondary outcomes

  1. Disease Comorbidities

    Time frame: From patient admission to an evaluation period extending up to the latest follow-up, estimately up to 3 years

    Systemic changes accompanied with Pituitary Complex and Rare Diseases

  2. Postoperative complications

    Time frame: Postoperative one week and extends to the latest follow-up, estimated at up to 3 years

    adverse events or medical issues that arise after a surgical procedure on the pituitary diseases.These complications can include various problems such as bleeding, infection, hormonal imbalances, cerebrospinal fluid leaks, vision changes, or neurological deficits

Study contacts

Contact information is provided by the study sponsor or research team.

Yong Yao, MD

CONTACT

[email protected]

+8669152530

Sponsors and collaborators

Lead sponsor

Peking Union Medical College Hospital

Other

Registry information

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
May 30, 2024
Registry last updated
May 30, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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