Clinical Applications of Advanced Ophthalmic Imaging

Observational Phase 1 Group

Inclusion criteria

• Self-reported normal healthy subjects;
• Clinical diagnosis of Alzheimer's Disease, mild cognitive impairment, multiple sclerosis, dry eye, myopia, diabetics and stroke;
• Who can keep the eye open for imaging.

Exclusion criteria

• who can not read and sign the ICF;
• who can not receiving ophthalmic imaging;
• who cannot tolerate bright light during imaging.

Interventional Phase 2 Group:

Inclusion criteria

The participant will be eligible for entry in the study if s/he:

• Is at least 18 years old and has full legal capacity to volunteer;
• Has read and signed the IRB Informed Consent Document;
• Is willing and able to follow participant instructions;
• Has clear corneas and crystalline lens;
• Initial visual acuities were 20/80 or better;
• MTHFR C677TT homozygous, or MTHFR C677T/A1298C compound heterozygous with mild to moderate micro-aneurismal vascular retinopathy disease;
• Hemoglobin A1c is 10 or less;
• Normotensive with or without medications;
• Without retinal capillary dropout or macular edema;
• Blood homocysteine > 9.

Exclusion criteria

The subjects will be ineligible for entry into the study if s/he:

• Has an active ocular disease;
• Has had surgery or an eye injury within 6 months.