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Completed

NCT Number: NCT03966638

Clinical and Radiological Evaluation of Meniscal Healing After Percutaneous Intra-meniscal Injection of Platelet-rich Plasma (PRP)

Meniscal lesions are a common pathology among athletes, and have an impact on the daily or sporting practice of patients. The consequences of surgical treatment are sometimes heavy.

Platelet-rich-plasma (PRP) has been shown to be effective in healing tendon and ligament lesions.

PRP has been injected under ultrasound in tendons or intra-articularly for several years.

This technique of meniscal percutaneous injection of PRP is now carried out for more than 2 years in our hospital, with satisfactory preliminary results, without any complication.

All patients in our study received an intra-meniscal injection of PRP, under echographic control. They were evaluated clinically and by Magnetic Resonance Imaging (MRI) before and at 6 months of the injection.

The aim of the study is to evaluate the efficacy of intra-meniscal injection of PRP on the symptomatology of the patients (pain, sport activities and daily life) at 6 months post-treatment.

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Key information

Conditions

Meniscus Lesion

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Radiology, Croix-Rousse Hospital, Hospices Civils de Lyon

Lyon, 69004, France

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • isolated symptomatic meniscal lesion
  • lesion confirmed by MRI
  • grade II or III lesion touching the peripheral involvement of the middle segment,
  • lesion treated by percutaneous intra meniscal PRP's injection
  • IKDC score measured before injection and 6 months post-injection

Exclusion criteria

  • other painful etiology of the knee
  • emergency surgical management (luxation, bucket handle) or not (indication validated by the surgeon, meniscectomy or meniscal suture)
  • impossibility to perform the procedure (non visible lesion, morphology of the patient, cutaneous infection, coagulation treatment in progress)

Treatment and study plan

Intra-meniscal injection of platelet-rich plasma

Procedure

Intra-meniscal injection of platelet-rich plasma under echographic control

Primary outcomes

  1. Variation of International Knee Documentation Committee (IKDC) score

    Time frame: Between 0 and 6 months post injection

    The variation of IKDC score between before injection and 6 months post-injection will be calculated. The IKDC score ranges from 0 to 100 and is interpreted as a measure of function with higher scores representing higher levels of function.

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Official study title

Clinical and Radiological Evaluation of Meniscal Healing After Percutaneous Intra-meniscal

Acronym: COMPARE

Important dates

Study start
2017
Primary completion
2020
Study completion
2020
First posted
May 29, 2019
Registry last updated
Mar 21, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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