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NCT Number: NCT07199725

Clinical and Radiographic Evaluation of Natural Bovine Bone With Hyaluronic Acid on Osseointegration of Immediate Implant.

the goal of this study is to evaluate the effective of natural bovine bone with hyaluronic acid on osseointegration of immediate implants in single rooted badly decayed maxillary anterior teeth and premolars. the main question it aims to answer is does natural bovine with hyaluronic acid affects osseointegration of immediate implants.

the study compares immediate implants followed by grafting with natural bovine bone with hyaluronic acid to immediate implants without grafting.

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Key information

Conditions

Dental Implants

Age range

21 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2 / Phase 3

Primary location

Suez Canal University

Ismailia, 41511, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • medically free patients, good oral hygiene, no periapical lesions around teeth to be extracted

Exclusion criteria

  • patients with bone or soft tissue defects, poor oral hygiene, heavy smoking, bruxism, severe periodontal disease

Treatment and study plan

immediate dental implant

Combination Product

control group: 8 teeth were extracted then 8 immediate implants were placed without bone grafting

immediate dental implant, natural bovine bone substitute material

Combination Product

study group: 8 teeth were extracted then received 8 immediate implants followed by grafting with natural bovine bone substitute material with hyaluronic acid

Primary outcomes

  1. Bone density

    Time frame: baseline (immediately) and 6 months

    using cone beam CT bone density was measured around the implant in housefield units immediately after implant placement and after 6 months.

  2. implant stability

    Time frame: Baseline (immediately) and after 4 months

    using Osstell device, implant stability was measured immediately after implant placement and after 4 months

Secondary outcomes

  1. Bone width

    Time frame: Baseline (immediately) and 6 months

    using cone beam CT, buccal bone width was measured from the mid surface of the implant immediately after implant placement and after 6 months.

Sponsors and collaborators

Lead sponsor

Suez Canal University

Other

Registry information

Official study title

Clinical and Radiographic Evaluation of Natural Bovine Bone With Hyaluronic Acid on Osseointegration of Immediate Implant: A Randomized Clinical Study

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Sep 30, 2025
Registry last updated
Sep 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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