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NCT Number: NCT07310732

Clinical and Radiographic Assessment of Efficacy of Modified Minimally Invasive SurgicalTechnique (M-MIST) Alone and Combined With Enamel Matrix Proteins and Ox-derived Bone Graft in the Treatment of Single Bone Defects Between Teeth.

This study was performed to investigate the adjunctive clinical benefit of the application of enamel matric derivatives and xenograft with the modified minimally invasive surgical technique in the treatment of isolated intrabony defects in periodontally compromised subjects.

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Key information

Conditions

Periodontal Diseases Alveolar Bone Loss Bone Diseases Bone Resorption Mouth Diseases Musculoskeletal Diseases Periodontal Atrophy Periodontal Bone Loss Stomatognathic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Periodontics, Rungta College of Dental Sciences and Research

Bhilai, Chhattisgarh, 490023, India

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • at least one site associated with an intrabony defect of ≥3 mm involving predominantly the interdental space of the tooth
  • patients with optimal compliance

Exclusion criteria

  • Patients with uncontrolled or poorly controlled diabetes
  • history of long-term use of medications
  • allergic to medications
  • pregnant or lactating women
  • smokers/users of other tobacco products

Treatment and study plan

modified minimally invasive surgical technique

Procedure

modified minimally invasive surgical technique alone in interdental area

modified minimally invasive surgical technique plus emdogain

Procedure

modified minimally invasive surgical technique with application of enamel matrix proteins in interdental area

modified minimally invasive surgical technique plus emdogain and xenograft

Procedure

modified minimally invasive surgical technique with application of enamel matrix proteins and placement of bovine bone graft in interdental area

Primary outcomes

  1. Probing Pocket Depth

    Time frame: 24 weeks

    The depth of probe penetration into the pocket (millimeters) is measured from the gingival margin using an UNC-15 probe.

  2. Clinical Attachment Level

    Time frame: 24 weeks

    The distance from the base of the pocket to cemento-enamel junction (millimeters) is measured using an UNC-15 probe.

Secondary outcomes

  1. Full mouth plaque score

    Time frame: 24 weeks

    Turesky Modification of Quigley-Hein Index used to assess plaque buildup across all tooth surfaces (buccal, lingual, mesial, distal) with scoring 0 (no plaque) to 5 (heavy plaque)

  2. Full mouth bleeding score

    Time frame: 24 weeks

    Probe is inserted and withdrawn at the distal point of the tooth and monitored for bleeding within 10 seconds. Registered with (+) availability of provoked bleeding and with (-) its absence.

  3. Mean defect depth

    Time frame: 24 weeks

    measured as the distance fromt the alveolar crest to the base of the defect (in CBCT)

Sponsors and collaborators

Lead sponsor

Rungta College of Dental Sciences and Research

Other

Registry information

Official study title

Clinical and Tomographic Efficacy of the Modified Minimally Invasive Surgical Technique (M-MIST) Alone and Combined With Enamel Matrix Derivative (EMD) and Bone Mineral Derived Xenograft (BMDX), in the Treatment of Isolated, Inter-dental Intra-bony Defects

Important dates

Study start
2022
Primary completion
2024
Study completion
2025
First posted
Dec 30, 2025
Registry last updated
Dec 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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