Clinical and Microbiological Relationships Between Periodontitis and Abdominal Aorta Aneurism: an Case Control Study

Aorta Abdominal aneurism (AAA) is a chronic degenerative disorder leading to the dilation and eventually to the rupture of the aortic wall. The pathology presents risk factors such as aging, atherosclerosis, male gender, cigarette smoking, pulmonary emphysema and high blood pressure.The vascular wall destruction is characterized by a remodeling of the extracellular matrix (ECM), the presence of an inflammatory infiltrate of macrophages and lymphocytes associated increase in production of MMPs. A similar destruction mechanisms is found in periodontitis a chronic inflammatory diseases characterized by gram-negative bacteria species that are able to degrade ECM of the tooth supporting tissues and leading finally to tooth loss .Moreover, relationships between periodontitis and cardiovascular disease have already been demonstrated. These associations are considered to be initiated by transient or prolonged bacteremia due to dissemination of oral bacteria or their products into the bloodstream . The periopathogens, more specifically Porphyromonas gingivalis (Pg), were observed in atherosclerosis and aneurysm specimens as well as in coronary heart disease and endocarditis The association between periodontitis and Abdominal Aortic Aneurysms (AAA) has not often been studied especially from a clinical aspect. The mechanisms that induce the initiation, the development or the recurrence and the rupture of AAA after a period of quiescence not well studied and are therefore still unknown.

The aim of this clinical observational case controlled study is to search for a possible relationship between periodontal disease and rapid growth of AAA. Patients presenting stable or unstable AAA will be screened for the degree of periodontitis, for the type of oral microbiology and periodontopathogen markers present in the blood stream.

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Key information

Conditions

Abdominal Aorta Aneurism Dentulous Mouth Diseases Periodontal Diseases Periodontitis Stomatognathic Diseases

Sex eligibility

All sexes

Study type

Observational

About this study

31 consecutive dentulous patients diagnosed for AAA requiring a cardiovascular surgery (instable AAA) and 31 consecutive dentulous patients with stable AAA (no need for cardiovascular surgery) will be recruited from the Cardiovascular Surgery Department of the University Hospital of Liège (Faculty of Medicine, University of Liège, Belgium - Pr. N. Sakalihasan). The 62 patients will be subjected to:

Full clinical periodontal parameter assessment
Microbiological analyses of saliva,
Supra- and sub- gingival microbiological test
Blood test for biomarker analysis.
Imaging (echography, CT-Scans)measurments

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

AAA
dentulous
ability to come in Hospital

Exclusion criteria

diseases of connective tissue: rheumatoid arthritis, systemic lupus erythematosus, systemic sclerodermia, Crohn disease, Marfan syndrome, Heler Danlos syndrome, polymyosite/dermatomyosite, mix connectivite (MCDT)
aneurysms of the lower limbs (femoral or popliteal)
contraindication to the scanner
participation of another clinical trial 30 days before baseline
patient with risk oslerien
taking antibiotics during the 3 months preceding the inclusion
obese patients (BMI ≥ 30 kg/m2)
immunosuppressant drugs or chemotherapy

Treatment and study plan

cross sectional

Other

Primary outcomes

pocked depth correlated with AAA stability

Time frame: june 2017

Periodontal clinical parameters such as pocked depth (PD, millimeter) will be correlated with AAA stability.

Secondary outcomes

pocked depth correlated with abdominal aortic aneurysm diametres such as anterior -posterior

Time frame: March 2018

Periodontal clinical parameters such as pocked depth (PD, millimeter) will be correlated with abdominal aortic aneurysm diametres such as anterior -posterior (AP,millimeter)

Sponsors and collaborators

Lead sponsor

University of Liege

Other

Collaborators

KU Leuven

Registry information

Important dates

Study start: 2015
Primary completion: 2015
Study completion: 2018
First posted: Dec 6, 2018
Registry last updated: Dec 14, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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